Detailed information of TA system TA217329

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4574710..4575387
• Replicon: chromosome
• Accession: NZ_CP083784
• Organism: Klebsiella pneumoniae strain KSB2_6C isolate KSB2_6C

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LD127_RS22585
• Protein ID: WP_069303595.1
• Coordinates: 4574710..4575030 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LD127_RS22590
• Protein ID: WP_110216231.1
• Coordinates: 4575064..4575387 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LD127_RS22560 (4569889)	4569889..4570773	+	885	WP_004192285.1	RES domain-containing protein	-
LD127_RS22565 (4570972)	4570972..4571160	-	189	Protein_4420	transposase	-
LD127_RS22570 (4571177)	4571177..4572288	-	1112	Protein_4421	IS3 family transposase	-
LD127_RS22575 (4572682)	4572682..4573689	-	1008	WP_017880110.1	restriction endonuclease	-
LD127_RS22580 (4573766)	4573766..4574596	-	831	WP_110216229.1	DUF4942 domain-containing protein	-
LD127_RS22585 (4574710)	4574710..4575030	-	321	WP_069303595.1	TA system toxin CbtA family protein	Toxin
LD127_RS22590 (4575064)	4575064..4575387	-	324	WP_110216231.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LD127_RS22595 (4575400)	4575400..4575870	-	471	WP_069303593.1	DNA repair protein RadC	-
LD127_RS22600 (4575941)	4575941..4576762	-	822	WP_069303592.1	DUF932 domain-containing protein	-
LD127_RS22605 (4576861)	4576861..4577073	-	213	WP_110184539.1	hypothetical protein	-
LD127_RS22610 (4577155)	4577155..4577514	-	360	WP_110184538.1	hypothetical protein	-
LD127_RS22615 (4577601)	4577601..4578065	-	465	WP_069303590.1	hypothetical protein	-
LD127_RS22620 (4578120)	4578120..4578797	-	678	WP_069303589.1	WYL domain-containing protein	-
LD127_RS22625 (4578857)	4578857..4579585	-	729	WP_069303588.1	DUF3944 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4563051..4599261	36210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12077.65 Da
• Isoelectric Point: 5.0356

>T217329 WP_069303595.1 NZ_CP083784:c4575030-4574710 [Klebsiella pneumoniae]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFQDDEAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQDQTPFLTATDILRARRATGLINT

Nucleotide

• Length: 321 bp

>T217329 NZ_CP114156:c5135249-5134962 [Klebsiella michiganensis]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAATAAGTAATCTAAGAAAACATGGAATCCGGTTTGAGGAAGCGGT
GCTCGTCTTAGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12031.59 Da
• Isoelectric Point: 5.4947

>AT217329 WP_110216231.1 NZ_CP083784:c4575387-4575064 [Klebsiella pneumoniae]
MPFTLSHGWGIQSDITQRFGARLVQEGNRLHYLADRASLTGSFSPEQLQSLENAFPLFIEQLGNMLRSGELNPQQQHQMT
IQLTGLTCIADTLSSWGYVYLTVYPAQ

Nucleotide

• Length: 324 bp

>AT217329 NZ_CP114156:c5134975-5134673 [Klebsiella michiganensis]
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGACGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGATATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG