Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3938223..3938842 Replicon chromosome
Accession NZ_CP083784
Organism Klebsiella pneumoniae strain KSB2_6C isolate KSB2_6C

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LD127_RS19485 Protein ID WP_002892050.1
Coordinates 3938624..3938842 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LD127_RS19480 Protein ID WP_002892066.1
Coordinates 3938223..3938597 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD127_RS19470 (3933375) 3933375..3934568 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LD127_RS19475 (3934591) 3934591..3937737 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LD127_RS19480 (3938223) 3938223..3938597 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LD127_RS19485 (3938624) 3938624..3938842 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LD127_RS19490 (3939001) 3939001..3939567 + 567 WP_004191639.1 maltose O-acetyltransferase -
LD127_RS19495 (3939539) 3939539..3939679 - 141 WP_004147370.1 hypothetical protein -
LD127_RS19500 (3939700) 3939700..3940170 + 471 WP_002892026.1 YlaC family protein -
LD127_RS19505 (3940145) 3940145..3941596 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LD127_RS19510 (3941697) 3941697..3942395 + 699 WP_002892021.1 GNAT family protein -
LD127_RS19515 (3942392) 3942392..3942532 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LD127_RS19520 (3942532) 3942532..3942795 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217327 WP_002892050.1 NZ_CP083784:3938624-3938842 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T217327 NZ_CP114156:4458730-4458948 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT217327 WP_002892066.1 NZ_CP083784:3938223-3938597 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT217327 NZ_CP114156:4458329-4458703 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCGACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCTGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References