Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1692201..1693972 Replicon chromosome
Accession NC_008543
Organism Burkholderia cenocepacia HI2424

Toxin (Protein)


Gene name doc Uniprot ID B1K293
Locus tag BCEN2424_RS23280 Protein ID WP_011547425.1
Coordinates 1693055..1693972 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1K294
Locus tag BCEN2424_RS23275 Protein ID WP_011547426.1
Coordinates 1692201..1693058 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCEN2424_RS23255 1687364..1688854 - 1491 WP_011547430.1 aldehyde dehydrogenase -
BCEN2424_RS23260 1688927..1689754 - 828 WP_011547429.1 aspartate dehydrogenase -
BCEN2424_RS23265 1689747..1691414 - 1668 WP_011547428.1 thiamine pyrophosphate-binding protein -
BCEN2424_RS23270 1691407..1692204 - 798 WP_011547427.1 SDR family oxidoreductase -
BCEN2424_RS23275 1692201..1693058 - 858 WP_011547426.1 IclR family transcriptional regulator Antitoxin
BCEN2424_RS23280 1693055..1693972 - 918 WP_011547425.1 alpha/beta hydrolase Toxin
BCEN2424_RS23285 1693991..1694518 - 528 WP_011547424.1 cupin domain-containing protein -
BCEN2424_RS23290 1694553..1695323 - 771 WP_011547423.1 SDR family oxidoreductase -
BCEN2424_RS23295 1695316..1696386 - 1071 WP_011547422.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BCEN2424_RS23300 1696447..1696758 - 312 WP_011547421.1 hypothetical protein -
BCEN2424_RS23305 1696760..1697077 - 318 WP_006478721.1 non-heme iron oxygenase ferredoxin subunit -
BCEN2424_RS23310 1697512..1698591 + 1080 WP_011547420.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(58-286)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 31280.60 Da        Isoelectric Point: 7.7325

>T21732 WP_011547425.1 NC_008543:c1693972-1693055 [Burkholderia cenocepacia HI2424]
MSVIDKRERERDRTAAFAALLGQFPEQRCAAGAAGAIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGA
SRRVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLVRVMPARIAGLLLISPAGGYG
SAPAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRG
RTAVAVGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDPQRGPA

Download         Length: 918 bp

>T21732 NC_008543:c1693972-1693055 [Burkholderia cenocepacia HI2424]
ATGAGTGTCATCGACAAACGCGAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCA
GCGTTGCGCGGCCGGCGCGGCGGGCGCGATCGGCTACCGTGAGGCGGGTGCAGGCGAGGCCGGCGCGCAGCATGCGGGCC
GTGCGCTGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTGGGTGCA
TCGCGGCGCGTACTCGCGTGGGATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGA
TTACGCGGCATCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGA
TCATCGCGGGCGGCCTCGTCCGCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGC
AGCGCACCGGCCGAGACCCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGC
CGAGCAGCGCAGCGGCAACATGCTGTCCGGTTTCGCGAACGAGGAGGCAAAGGCATGGGTGCGCTGGAACATGGCGCGCA
TCGTGCCGGCCGGCTACGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGC
CGCACGGCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGT
CGGGCTGCAGGTGATTCCGCAGGCGGGGCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCGCTGATCGACACGT
TCTGTCGTCAGTGCGACCCACAGCGGGGGCCGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31315.76 Da        Isoelectric Point: 6.5054

>AT21732 WP_011547426.1 NC_008543:c1693058-1692201 [Burkholderia cenocepacia HI2424]
MSEPLQQNESDNAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT21732 NC_008543:c1693058-1692201 [Burkholderia cenocepacia HI2424]
ATGAGCGAACCGCTGCAACAAAACGAATCCGACAACGCGAAGGCCGAAGCCAGCTACGTCGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAACGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGTTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTTGACGCGCTGTACGACGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1K293

Antitoxin

Source ID Structure
AlphaFold DB B1K294

References