Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 213439..213965 | Replicon | plasmid pINF118_1 |
| Accession | NZ_CP083776 | ||
| Organism | Klebsiella pneumoniae strain INF118 isolate INF118 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LB478_RS28295 | Protein ID | WP_000323025.1 |
| Coordinates | 213439..213726 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | J5W3H0 |
| Locus tag | LB478_RS28300 | Protein ID | WP_004196370.1 |
| Coordinates | 213726..213965 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LB478_RS28250 (LB478_28250) | 208770..208994 | - | 225 | WP_014343499.1 | hypothetical protein | - |
| LB478_RS28255 (LB478_28255) | 209005..209217 | - | 213 | WP_019706020.1 | hypothetical protein | - |
| LB478_RS28260 (LB478_28260) | 209278..209634 | - | 357 | WP_019706019.1 | hypothetical protein | - |
| LB478_RS28265 (LB478_28265) | 210475..210792 | - | 318 | WP_015065519.1 | hypothetical protein | - |
| LB478_RS28270 (LB478_28270) | 210807..211157 | - | 351 | WP_032425551.1 | hypothetical protein | - |
| LB478_RS28275 (LB478_28275) | 211154..211426 | - | 273 | WP_032425552.1 | hypothetical protein | - |
| LB478_RS29460 (LB478_28280) | 212124..212282 | - | 159 | WP_014343509.1 | type I toxin-antitoxin system Hok family toxin | - |
| LB478_RS28290 (LB478_28290) | 212354..213388 | + | 1035 | Protein_223 | IS481 family transposase | - |
| LB478_RS28295 (LB478_28295) | 213439..213726 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LB478_RS28300 (LB478_28300) | 213726..213965 | - | 240 | WP_004196370.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LB478_RS28305 (LB478_28305) | 213990..214088 | + | 99 | Protein_226 | protein YdfV | - |
| LB478_RS28310 (LB478_28310) | 214216..214581 | + | 366 | WP_009651956.1 | hypothetical protein | - |
| LB478_RS28315 (LB478_28315) | 214625..215362 | + | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| LB478_RS28320 (LB478_28320) | 215376..216065 | + | 690 | WP_004196322.1 | hypothetical protein | - |
| LB478_RS28325 (LB478_28325) | 216096..217472 | - | 1377 | Protein_230 | chromate efflux transporter | - |
| LB478_RS28330 (LB478_28330) | 217429..218406 | - | 978 | WP_004196334.1 | chromate resistance protein | - |
| LB478_RS28335 (LB478_28335) | 218436..218628 | + | 193 | Protein_232 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ | 1..256803 | 256803 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T217313 WP_000323025.1 NZ_CP083776:c213726-213439 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T217313 NZ_CP114149:1988850-1989182 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 4.3894
>AT217313 WP_004196370.1 NZ_CP083776:c213965-213726 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
Download Length: 240 bp
>AT217313 NZ_CP114149:1988592-1988849 [Klebsiella michiganensis]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGATGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGATGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|