Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1418519..1419158 Replicon chromosome
Accession NC_008543
Organism Burkholderia cenocepacia HI2424

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N9F707
Locus tag BCEN2424_RS22095 Protein ID WP_011547639.1
Coordinates 1418519..1418929 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1K469
Locus tag BCEN2424_RS22100 Protein ID WP_011547638.1
Coordinates 1418922..1419158 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCEN2424_RS22065 1413901..1414200 - 300 WP_011547642.1 hypothetical protein -
BCEN2424_RS22070 1414412..1414660 - 249 WP_006478971.1 hypothetical protein -
BCEN2424_RS22075 1415110..1415358 - 249 WP_011547641.1 hypothetical protein -
BCEN2424_RS22080 1415355..1416602 - 1248 WP_011547640.1 alkaline phosphatase family protein -
BCEN2424_RS22085 1417172..1417435 - 264 WP_006483034.1 translation initiation factor IF-1 -
BCEN2424_RS22090 1417902..1418105 - 204 WP_006483056.1 cold-shock protein -
BCEN2424_RS22095 1418519..1418929 - 411 WP_011547639.1 type II toxin-antitoxin system VapC family toxin Toxin
BCEN2424_RS22100 1418922..1419158 - 237 WP_011547638.1 DNA-binding protein Antitoxin
BCEN2424_RS22105 1419649..1420875 + 1227 WP_012339914.1 acyltransferase -
BCEN2424_RS22110 1420895..1421719 - 825 WP_011547636.1 hypothetical protein -
BCEN2424_RS37065 1421931..1422152 + 222 WP_027811879.1 hypothetical protein -
BCEN2424_RS35780 1422536..1423411 + 876 WP_011547634.1 hypothetical protein -
BCEN2424_RS37070 1423521..1423841 - 321 WP_166488159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1414412..1432470 18058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15202.37 Da        Isoelectric Point: 6.8816

>T21731 WP_011547639.1 NC_008543:c1418929-1418519 [Burkholderia cenocepacia HI2424]
MIDTNVISEIRKGRRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWIAMILSGYAPNILP
VDIETSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 411 bp

>T21731 NC_008543:c1418929-1418519 [Burkholderia cenocepacia HI2424]
TTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAGGCGAACCAATCGCGGCGTGCGGGCGTTCTTCAGGCAGGC
CGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGTTGCGGCGCGGCGTCGACCTGATCCGTCATC
GCGGCGATCATAGCCAGGCGTCGGCGCTCGAGGCCTGGATCGCGATGATCCTGTCGGGCTATGCGCCGAACATCCTGCCG
GTCGATATCGAGACCAGCCAGATGTGGGGGCATTTGCGGGTGCCCGATCCGACGCACGAACTCGACAAGCTGATCGCGGC
CACCGCGCTGATCAACGATCTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACTGGCGTCCGGTTGCTGAATC
CGTTCGACTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8692.75 Da        Isoelectric Point: 5.0916

>AT21731 WP_011547638.1 NC_008543:c1419158-1418922 [Burkholderia cenocepacia HI2424]
MANLLVRNVDDTIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLLSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT21731 NC_008543:c1419158-1418922 [Burkholderia cenocepacia HI2424]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTATCGTTCAAAGCCTGCGTGAGCAGGCGGCGGCCAATGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGGACATTTGCTCAAGTGCTGCTGA
GCATGCCGGAGGTGGGCGAGGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N9F707

Antitoxin

Source ID Structure
AlphaFold DB B1K469

References