Detailed information of TA system TA217307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5070995..5072676
• Replicon: chromosome
• Accession: NZ_CP083775
• Organism: Klebsiella pneumoniae strain INF118 isolate INF118

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LB478_RS25290
• Protein ID: WP_224440603.1
• Coordinates: 5070995..5071912 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LB478_RS25295
• Protein ID: WP_004177809.1
• Coordinates: 5071918..5072676 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB478_RS25270 (LB478_25270)	5066301..5067821	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LB478_RS25275 (LB478_25275)	5067818..5068816	+	999	WP_031592479.1	ribose ABC transporter permease	-
LB478_RS25280 (LB478_25280)	5068847..5069788	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LB478_RS25285 (LB478_25285)	5069863..5070870	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
LB478_RS25290 (LB478_25290)	5070995..5071912	-	918	WP_224440603.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LB478_RS25295 (LB478_25295)	5071918..5072676	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LB478_RS25300 (LB478_25300)	5072762..5073490	-	729	WP_002885152.1	response regulator transcription factor	-
LB478_RS25305 (LB478_25305)	5073763..5075910	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
LB478_RS25310 (LB478_25310)	5076140..5076826	+	687	WP_134918859.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34736.20 Da
• Isoelectric Point: 5.2584

>T217307 WP_224440603.1 NZ_CP083775:c5071912-5070995 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGEVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRCEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T217307 NZ_CP114134:c3713325-3713191 [Xanthomonas fragariae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAATACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCTGGCGAGAAAGTGGAAGACGCTGCGCGCAAGTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT217307 WP_004177809.1 NZ_CP083775:c5072676-5071918 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT217307 NZ_CP114134:c3713558-3713406 [Xanthomonas fragariae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCTTGTTTTCGGCCGGCGTGATGACTGGCTGTAACACCGTTGCTGGCGC
CGGCAAGGATATGCAACGCGCGGGCAGCAAGGTCGAAAAGAAGGCCGATAACTGCAGCGACGGTAAATGCTGA

Structures

Antitoxin

• AlphaFold DB: A6TH05