Detailed information of TA system TA217306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4909330..4909846
• Replicon: chromosome
• Accession: NZ_CP083775
• Organism: Klebsiella pneumoniae strain INF118 isolate INF118

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LB478_RS24475
• Protein ID: WP_021469513.1
• Coordinates: 4909330..4909614 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: LB478_RS24480
• Protein ID: WP_002886901.1
• Coordinates: 4909604..4909846 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB478_RS24450 (LB478_24450)	4904725..4904988	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
LB478_RS24455 (LB478_24455)	4905118..4905291	+	174	WP_032408826.1	hypothetical protein	-
LB478_RS24460 (LB478_24460)	4905294..4906037	+	744	WP_224440596.1	MurR/RpiR family transcriptional regulator	-
LB478_RS24465 (LB478_24465)	4906394..4908532	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
LB478_RS24470 (LB478_24470)	4908862..4909326	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LB478_RS24475 (LB478_24475)	4909330..4909614	-	285	WP_021469513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LB478_RS24480 (LB478_24480)	4909604..4909846	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LB478_RS24485 (LB478_24485)	4909924..4911834	-	1911	WP_004152270.1	PRD domain-containing protein	-
LB478_RS24490 (LB478_24490)	4911857..4913011	-	1155	WP_002886900.1	lactonase family protein	-
LB478_RS24495 (LB478_24495)	4913078..4913818	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.95 Da
• Isoelectric Point: 10.4962

>T217306 WP_021469513.1 NZ_CP083775:c4909614-4909330 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T217306 NZ_CP114134:3043906-3044397 [Xanthomonas fragariae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCGACCGGTGCGTCACGGGCCTTCGTTGCCTGCGCGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCAGACCAG
ATCCCCGTGGTGGTGCTTGGCAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGGTGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTTGAGCCCTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT217306 WP_002886901.1 NZ_CP083775:c4909846-4909604 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT217306 NZ_CP114134:3043619-3043909 [Xanthomonas fragariae]
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTGCGCATCAAGCCGGAGGAGCGCAGTCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCGCAGCCAGCCCGGACGCCTACGCCGCCTTCTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0