Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4192902..4193521 Replicon chromosome
Accession NZ_CP083775
Organism Klebsiella pneumoniae strain INF118 isolate INF118

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LB478_RS21075 Protein ID WP_002892050.1
Coordinates 4193303..4193521 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LB478_RS21070 Protein ID WP_002892066.1
Coordinates 4192902..4193276 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB478_RS21060 (LB478_21060) 4188054..4189247 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LB478_RS21065 (LB478_21065) 4189270..4192416 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit AcrB -
LB478_RS21070 (LB478_21070) 4192902..4193276 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LB478_RS21075 (LB478_21075) 4193303..4193521 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LB478_RS21080 (LB478_21080) 4193680..4194246 + 567 WP_002892030.1 maltose O-acetyltransferase -
LB478_RS21085 (LB478_21085) 4194218..4194358 - 141 WP_004147370.1 hypothetical protein -
LB478_RS21090 (LB478_21090) 4194379..4194849 + 471 WP_002892026.1 YlaC family protein -
LB478_RS21095 (LB478_21095) 4194824..4196275 - 1452 WP_213490397.1 PLP-dependent aminotransferase family protein -
LB478_RS21100 (LB478_21100) 4196376..4197074 + 699 WP_002892021.1 GNAT family protein -
LB478_RS21105 (LB478_21105) 4197071..4197211 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LB478_RS21110 (LB478_21110) 4197211..4197474 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217304 WP_002892050.1 NZ_CP083775:4193303-4193521 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T217304 NZ_CP114134:c781374-780775 [Xanthomonas fragariae]
ATCGTCCATCGCGACAACCTGCCCTGGATTATGGACAACGGCCTGCACTGCGCTAATGGCGGGGTGCAGAGCCCAGGCTG
GGTGAGCATCGGCAATCCGGAATTGATCGCCAAACGCGCCAATCATCCTGTGTCGCTCGCACCGGGCGGCTTCCTGAACG
ATTACGTGCCCTTTTACTTCACTCCATTTTCGCCGATGCTGCGCAACATCCATACCGGCTGGGGAGGTATCCAACAACGG
TCGAATGAGGAGATTGTGATACTTGTTTCCAGCCTGCGTCAGGTCGCGGCACGAGGATGGCCTTTTCTGTTCACCGATGG
CCACGCTTACTCTCAGTTGACAACTTTCCATTCCGATTTGGCCAAGCTCGACAAGATCGACTGGCCACTGCTTCAGGCGC
GCGATTTTCGGCGCGATCAGGAGGACCCGGCCAAGTTCGAGCGATATCAGGCGGAAGCGCTGGTTCACCGACACTTGCCG
GTCGATGGCCTGTGCGGCATCGTGTGTTATACGGACGATCTGAAGCTTTCCATCGAGCGTCAGCTTAAGGCTCGCAACCT
CACACTTCCAGTTCATGCCCGCACCGAGTGGTACTTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT217304 WP_002892066.1 NZ_CP083775:4192902-4193276 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT217304 NZ_CP114134:c780775-779705 [Xanthomonas fragariae]
ATGATTATGTTCACGCAAGGCAATCTGCTGCAGGCGCGCGTCGAGGCATTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAAGGCATCGCGCTGATGTTCAAGGAGCGCTTCAACGAAAATTTCCTCCGATATGCCGCTGCCTGCAAGGCAAAGC
AGGTGCGCACGGGCAAGGTGTTCGTCACCGAAGCCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACAAAA
CAGCACTGGCGTGGCGATTCGCGCATCGAATGGATCACCGAAGGGCTGCAGGATCTGCGCCTGTTCCTGATCGAGAACAA
GGTCGGATCGATTGCCATCCCGCCACTGGGCGCCGGCAATGGCGGGTTGGACTGGGCTGACGTGCGTCCACTGATCGAAG
AGGCGCTGGCCGGTCTGGATACCGACATTCTCGTGTTCGAGCCCACTGTGAAGTATCAAAACGTCGCAAAGCGCTCCGGC
GTGGAAAAGCTGACTCCAGCACGCGCCTTGATTGCCGAACTGATACGTCGCTATTGGGTGCTAGGCGTGGAATGCAGCCT
GTTGGAAATCCAGAAGCTGGCATGGTTTCTTGAACGCAACATCGAGCGCGCAGGCTTGCCTACGCTGGATTTGCGCTTTG
CGCCACACAAATATGGCCCATATGCCGACCGTCTCCGCCATCTGCTGGACGGGCTGGACGGAAGCTATCTGCACTGTGAC
AAGCGAATCGGCGACGCTGATCCTATAGATGTCATCTGGTTCGATGACGCTCGCAAAAGCGTTGTCCAGGCCTATCTCAA
GAGCGAAGCAAAACAGTATGCTCCAGCACTGGAAGCCACTGCCGCCTTGATCGATGGTTTTGAAACCCCTTTTGGCATGG
AGTTGCTGGCAACGGTGGACTGGCTAATTGCGCAGGGGGGTGTCTGTCCGCAAGTGGCAGACATGCGCGAGGGCATACGC
AACTGGCCCGGTGGCGCTGACGCAGCTGTGCGGAAAGACAGATTGTTCGATGACCGCGCTCTAGGCATCGCGTTGGAACG
ACTGACATCCAGTGCAAGCGCAGTGACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References