Detailed information of TA system TA217303

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2726752..2728340
• Replicon: chromosome
• Accession: NZ_CP083775
• Organism: Klebsiella pneumoniae strain INF118 isolate INF118

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LB478_RS13760
• Protein ID: WP_213490682.1
• Coordinates: 2726752..2728074 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LB478_RS13765
• Protein ID: WP_224440767.1
• Coordinates: 2728074..2728340 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB478_RS13745 (LB478_13745)	2721808..2724309	+	2502	WP_009485242.1	fimbria/pilus outer membrane usher protein	-
LB478_RS13750 (LB478_13750)	2724297..2725301	+	1005	WP_040241874.1	fimbrial protein	-
LB478_RS13755 (LB478_13755)	2725443..2726735	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LB478_RS13760 (LB478_13760)	2726752..2728074	-	1323	WP_213490682.1	type II toxin-antitoxin system HipA family toxin	Toxin
LB478_RS13765 (LB478_13765)	2728074..2728340	-	267	WP_224440767.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LB478_RS13770 (LB478_13770)	2728606..2728932	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
LB478_RS13775 (LB478_13775)	2728929..2729429	-	501	WP_117100891.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LB478_RS13780 (LB478_13780)	2729407..2730786	-	1380	WP_213490680.1	nucleobase:cation symporter-2 family protein	-
LB478_RS13785 (LB478_13785)	2731132..2732286	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LB478_RS13790 (LB478_13790)	2732267..2733190	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49240.53 Da
• Isoelectric Point: 7.2494

>T217303 WP_213490682.1 NZ_CP083775:c2728074-2726752 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLEVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMAFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIENARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T217303 NZ_CP114133:c88519-88244 [Escherichia coli]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9902.28 Da
• Isoelectric Point: 8.5912

>AT217303 WP_224440767.1 NZ_CP083775:c2728340-2728074 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAEPAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT217303 NZ_CP114133:c88803-88519 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA