Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 206427..206953 Replicon plasmid pKSB1_9E_1
Accession NZ_CP083769
Organism Klebsiella pneumoniae strain KSB1_9E isolate KSB1_9E

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LB480_RS26875 Protein ID WP_000323025.1
Coordinates 206427..206714 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag LB480_RS26880 Protein ID WP_004196370.1
Coordinates 206714..206953 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB480_RS26840 (LB480_26840) 202098..202415 - 318 WP_015065519.1 hypothetical protein -
LB480_RS26845 (LB480_26845) 202430..202780 - 351 WP_032425551.1 hypothetical protein -
LB480_RS26850 (LB480_26850) 202777..203049 - 273 WP_032425552.1 hypothetical protein -
LB480_RS26855 (LB480_26855) 203905..205017 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
LB480_RS27550 (LB480_26860) 205096..205254 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
LB480_RS26870 (LB480_26870) 205326..206360 + 1035 Protein_228 IS481 family transposase -
LB480_RS26875 (LB480_26875) 206427..206714 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LB480_RS26880 (LB480_26880) 206714..206953 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LB480_RS26885 (LB480_26885) 206978..207076 + 99 Protein_231 protein YdfV -
LB480_RS26890 (LB480_26890) 207204..207569 + 366 WP_009651956.1 hypothetical protein -
LB480_RS26895 (LB480_26895) 207613..208350 + 738 WP_008460272.1 HupE/UreJ family protein -
LB480_RS26900 (LB480_26900) 208364..209053 + 690 WP_004196322.1 hypothetical protein -
LB480_RS26905 (LB480_26905) 209084..210460 - 1377 Protein_235 chromate efflux transporter -
LB480_RS26910 (LB480_26910) 210417..211394 - 978 WP_004196334.1 chromate resistance protein -
LB480_RS26915 (LB480_26915) 211424..211616 + 193 Protein_237 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..250893 250893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T217291 WP_000323025.1 NZ_CP083769:c206714-206427 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T217291 NZ_CP114130:c3100045-3099890 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT217291 WP_004196370.1 NZ_CP083769:c206953-206714 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT217291 NZ_CP114130:3100057-3100115 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References