Detailed information of TA system TA021729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 638372..639013
• Replicon: chromosome
• Accession: NC_008543
• Organism: Burkholderia cenocepacia HI2424

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3R9BGG7
• Locus tag: BCEN2424_RS18760
• Protein ID: WP_011548231.1
• Coordinates: 638675..639013 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BCEN2424_RS18755
• Protein ID: WP_006490972.1
• Coordinates: 638372..638671 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEN2424_RS18730	633550..634821	+	1272	WP_027811470.1	Rieske 2Fe-2S domain-containing protein	-
BCEN2424_RS18735	634836..635312	+	477	WP_011548235.1	aromatic-ring-hydroxylating dioxygenase subunit beta	-
BCEN2424_RS18740	635348..635674	+	327	WP_006479527.1	non-heme iron oxygenase ferredoxin subunit	-
BCEN2424_RS18745	635664..636884	+	1221	WP_011548234.1	FAD-dependent oxidoreductase	-
BCEN2424_RS18750	637037..638323	+	1287	WP_011548233.1	DUF445 domain-containing protein	-
BCEN2424_RS18755	638372..638671	-	300	WP_006490972.1	putative addiction module antidote protein	Antitoxin
BCEN2424_RS18760	638675..639013	-	339	WP_011548231.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BCEN2424_RS18765	639392..641032	+	1641	WP_011548230.1	acetolactate synthase large subunit	-
BCEN2424_RS18770	641061..642494	+	1434	WP_006479522.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

• Uncharacterized protein HI1420 (4-96)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12588.43 Da
• Isoelectric Point: 8.9594

>T21729 WP_011548231.1 NC_008543:c639013-638675 [Burkholderia cenocepacia HI2424]
MVDILQSVPYSAPTFSIRTTDVFEAWFAGLPDRVARRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMPAHLDME

Nucleotide

• Length: 339 bp

>T21729 NC_008543:c639013-638675 [Burkholderia cenocepacia HI2424]
ATGGTTGACATCCTGCAATCCGTGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGAAGCGTGGTT
CGCCGGCCTGCCGGATCGCGTCGCGCGGCGGCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTATTACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTCTGCGGCGGCGATAAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCCCGC
GCACCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10608.04 Da
• Isoelectric Point: 6.4771

>AT21729 WP_006490972.1 NC_008543:c638671-638372 [Burkholderia cenocepacia HI2424]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Nucleotide

• Length: 300 bp

>AT21729 NC_008543:c638671-638372 [Burkholderia cenocepacia HI2424]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
CTGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCCCGCGGCATGTCGC
AGGTCGCCCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Structures

Toxin

• AlphaFold DB: A0A3R9BGG7