Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4685772..4686288 Replicon chromosome
Accession NZ_CP083768
Organism Klebsiella pneumoniae strain KSB1_9E isolate KSB1_9E

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag LB480_RS23045 Protein ID WP_004894697.1
Coordinates 4685772..4686056 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LB480_RS23050 Protein ID WP_002886901.1
Coordinates 4686046..4686288 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB480_RS23020 (4681167) 4681167..4681430 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
LB480_RS23025 (4681560) 4681560..4681733 + 174 WP_002886906.1 hypothetical protein -
LB480_RS23030 (4681736) 4681736..4682479 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LB480_RS23035 (4682836) 4682836..4684974 + 2139 WP_060416058.1 anaerobic ribonucleoside-triphosphate reductase -
LB480_RS23040 (4685304) 4685304..4685768 + 465 WP_048968808.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LB480_RS23045 (4685772) 4685772..4686056 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LB480_RS23050 (4686046) 4686046..4686288 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LB480_RS23055 (4686366) 4686366..4688276 - 1911 WP_032412857.1 PRD domain-containing protein -
LB480_RS23060 (4688299) 4688299..4689453 - 1155 WP_004178372.1 lactonase family protein -
LB480_RS23065 (4689520) 4689520..4690260 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T217284 WP_004894697.1 NZ_CP083768:c4686056-4685772 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T217284 NZ_CP114130:2227553-2227708 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGCCAGACGGAGGTTGCTGTCTTCACAGCTTACGAATCTGAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT217284 WP_002886901.1 NZ_CP083768:c4686288-4686046 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT217284 NZ_CP114130:c2227541-2227483 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References