Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1594877..1595545 Replicon chromosome
Accession NC_008533
Organism Streptococcus pneumoniae D39

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPD_RS08400 Protein ID WP_001132285.1
Coordinates 1595366..1595545 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPD_RS08395 Protein ID WP_000961810.1
Coordinates 1594877..1595329 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPD_RS08370 (SPD_1572) 1590767..1591510 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPD_RS08375 (SPD_1573) 1591512..1592462 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
SPD_RS08380 (SPD_1574) 1592600..1593028 - 429 WP_000418176.1 NUDIX hydrolase -
SPD_RS08385 (SPD_1575) 1592994..1594097 - 1104 WP_000719717.1 M50 family metallopeptidase -
SPD_RS08390 (SPD_1576) 1594116..1594586 - 471 WP_000257105.1 DUF3013 family protein -
SPD_RS08395 (SPD_1577) 1594877..1595329 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPD_RS08400 1595366..1595545 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPD_RS08405 (SPD_1578) 1595682..1595861 - 180 WP_001809903.1 hypothetical protein -
SPD_RS08415 (SPD_1579) 1596026..1596265 - 240 WP_000818079.1 hypothetical protein -
SPD_RS08425 (SPD_1580) 1596535..1597806 + 1272 WP_001113205.1 replication-associated recombination protein A -
SPD_RS08435 (SPD_1582) 1598353..1599672 - 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
SPD_RS08440 (SPD_1583) 1599682..1600527 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T21727 WP_001132285.1 NC_008533:c1595545-1595366 [Streptococcus pneumoniae D39]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T21727 NC_008533:c1595545-1595366 [Streptococcus pneumoniae D39]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT21727 WP_000961810.1 NC_008533:c1595329-1594877 [Streptococcus pneumoniae D39]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT21727 NC_008533:c1595329-1594877 [Streptococcus pneumoniae D39]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATTAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References