Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1373681..1374598 | Replicon | chromosome |
| Accession | NZ_CP083763 | ||
| Organism | Bacillus velezensis strain DMB06 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | I2HQ15 |
| Locus tag | LAZ97_RS07310 | Protein ID | WP_007407256.1 |
| Coordinates | 1373852..1374598 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | I2HQ14 |
| Locus tag | LAZ97_RS07305 | Protein ID | WP_003154807.1 |
| Coordinates | 1373681..1373851 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LAZ97_RS07255 (LAZ97_07255) | 1368887..1369399 | + | 513 | WP_017417605.1 | sigma-70 family RNA polymerase sigma factor | - |
| LAZ97_RS07260 (LAZ97_07260) | 1369512..1370063 | + | 552 | Protein_1371 | terminase | - |
| LAZ97_RS07265 (LAZ97_07265) | 1370174..1370536 | + | 363 | WP_014721043.1 | hypothetical protein | - |
| LAZ97_RS07270 (LAZ97_07270) | 1370549..1370920 | + | 372 | WP_129093699.1 | XkdW family protein | - |
| LAZ97_RS07275 (LAZ97_07275) | 1370925..1371122 | + | 198 | WP_007610833.1 | XkdX family protein | - |
| LAZ97_RS07280 (LAZ97_07280) | 1371179..1371940 | + | 762 | WP_063636818.1 | hypothetical protein | - |
| LAZ97_RS07285 (LAZ97_07285) | 1371992..1372255 | + | 264 | WP_021493821.1 | hemolysin XhlA family protein | - |
| LAZ97_RS07290 (LAZ97_07290) | 1372269..1372532 | + | 264 | WP_003154813.1 | phage holin | - |
| LAZ97_RS07295 (LAZ97_07295) | 1372546..1373424 | + | 879 | WP_007407257.1 | N-acetylmuramoyl-L-alanine amidase | - |
| LAZ97_RS07300 (LAZ97_07300) | 1373459..1373584 | - | 126 | WP_003154809.1 | hypothetical protein | - |
| LAZ97_RS07305 (LAZ97_07305) | 1373681..1373851 | - | 171 | WP_003154807.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| LAZ97_RS07310 (LAZ97_07310) | 1373852..1374598 | - | 747 | WP_007407256.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| LAZ97_RS07315 (LAZ97_07315) | 1374702..1375700 | - | 999 | WP_017417610.1 | inorganic phosphate transporter | - |
| LAZ97_RS07320 (LAZ97_07320) | 1375713..1376330 | - | 618 | WP_003154804.1 | DUF47 domain-containing protein | - |
| LAZ97_RS07325 (LAZ97_07325) | 1376617..1377933 | - | 1317 | WP_063636817.1 | amino acid permease | - |
| LAZ97_RS07330 (LAZ97_07330) | 1378255..1379205 | + | 951 | WP_007610844.1 | ring-cleaving dioxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29077.57 Da Isoelectric Point: 4.7755
>T217267 WP_007407256.1 NZ_CP083763:c1374598-1373852 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
Download Length: 747 bp
>T217267 NZ_CP114128:c2524252-2523974 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6676.74 Da Isoelectric Point: 10.9273
>AT217267 WP_003154807.1 NZ_CP083763:c1373851-1373681 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
Download Length: 171 bp
>AT217267 NZ_CP114128:c2523974-2523690 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCTCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCTCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|