Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 536746..537332 Replicon chromosome
Accession NZ_CP083757
Organism Marinilongibacter aquaticus strain YYF0007

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LAG90_RS02260 Protein ID WP_261450606.1
Coordinates 536746..537045 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LAG90_RS02265 Protein ID WP_261450607.1
Coordinates 537051..537332 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAG90_RS02230 (LAG90_02235) 531926..533698 + 1773 WP_261450600.1 DGQHR domain-containing protein -
LAG90_RS02235 (LAG90_02240) 533904..534152 + 249 WP_261450601.1 type II toxin-antitoxin system ParD family antitoxin -
LAG90_RS02240 (LAG90_02245) 534145..534444 + 300 WP_261450602.1 type II toxin-antitoxin system RelE/ParE family toxin -
LAG90_RS02245 (LAG90_02250) 534527..535174 - 648 WP_261450603.1 site-specific integrase -
LAG90_RS02250 (LAG90_02255) 535279..535686 + 408 WP_261450604.1 hypothetical protein -
LAG90_RS02255 (LAG90_02260) 535755..536609 + 855 WP_261450605.1 FkbM family methyltransferase -
LAG90_RS02260 (LAG90_02265) 536746..537045 + 300 WP_261450606.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LAG90_RS02265 (LAG90_02270) 537051..537332 + 282 WP_261450607.1 putative addiction module antidote protein Antitoxin
LAG90_RS02270 (LAG90_02275) 537634..538608 - 975 WP_261450608.1 NAD(P)H-quinone oxidoreductase -
LAG90_RS02275 (LAG90_02280) 538621..539178 - 558 WP_261450609.1 hypothetical protein -
LAG90_RS02280 (LAG90_02285) 539347..540195 + 849 WP_261450610.1 LysR substrate-binding domain-containing protein -
LAG90_RS02285 (LAG90_02290) 540282..540860 + 579 WP_261450611.1 cyclic nucleotide-binding domain-containing protein -
LAG90_RS02290 (LAG90_02295) 540921..541352 + 432 WP_261450612.1 SRPBCC family protein -
LAG90_RS02295 (LAG90_02300) 541415..541996 + 582 WP_261450613.1 GDP-mannose pyrophosphatase NudK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(2-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11767.79 Da        Isoelectric Point: 10.0817

>T217264 WP_261450606.1 NZ_CP083757:536746-537045 [Marinilongibacter aquaticus]
MYFIEKTTEFDKWLKKLKDIRAKAKIIFRIQKIESDEHFGDCKPVGDGIRELRINYAKGYRVYFKEKGDKIIILLVGGDK
STQQKDIEKAKEIWEKLNK

Download         Length: 300 bp

>T217264 NZ_CP114128:c2248392-2248285 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10037.55 Da        Isoelectric Point: 7.1996

>AT217264 WP_261450607.1 NZ_CP083757:537051-537332 [Marinilongibacter aquaticus]
MKTSKFDIADYLDSKEMIAEYLNTALENGNNQDVINAIGHIAKAIGMTKISEETGLSRPSLYKALSDGAKPQFATIMKVL
KAIGGQIHINPTA

Download         Length: 282 bp

>AT217264 NZ_CP114128:2248445-2248506 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References