217262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 86625..87151 Replicon plasmid p1
Accession NZ_CP083755
Organism Serratia marcescens strain YL4

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LBP97_RS25175 Protein ID WP_000323025.1
Coordinates 86864..87151 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LBP97_RS25170 Protein ID WP_000534858.1
Coordinates 86625..86864 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBP97_RS25150 (LBP97_25185) 82953..84191 + 1239 WP_000219087.1 IS110-like element ISEsa2 family transposase -
LBP97_RS25155 (LBP97_25190) 84667..85239 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
LBP97_RS25160 (LBP97_25195) 85439..86362 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
LBP97_RS25165 (LBP97_25200) 86496..86600 - 105 Protein_93 protein YdfV -
LBP97_RS25170 (LBP97_25205) 86625..86864 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LBP97_RS25175 (LBP97_25210) 86864..87151 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LBP97_RS25180 (LBP97_25220) 87223..87381 + 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
LBP97_RS25185 (LBP97_25225) 87990..88310 - 321 WP_000332796.1 hypothetical protein -
LBP97_RS25190 (LBP97_25230) 88592..88795 - 204 WP_001015183.1 hypothetical protein -
LBP97_RS25195 (LBP97_25235) 88842..89192 - 351 WP_000743059.1 hypothetical protein -
LBP97_RS25200 (LBP97_25240) 89252..89854 - 603 WP_012695474.1 hypothetical protein -
LBP97_RS25205 (LBP97_25245) 89950..90894 - 945 WP_000778029.1 DUF5417 domain-containing protein -
LBP97_RS25210 (LBP97_25250) 91405..91581 + 177 WP_001371930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / tet(D) / mcr-9 / aph(6)-Id / aph(3'')-Ib / blaTEM-1B / fosA5 / sul1 / qacE / blaIMP-26 / dfrA19 / catA2 / blaSHV-12 - 1..316459 316459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T217262 WP_000323025.1 NZ_CP083755:86864-87151 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T217262 NZ_CP114128:1893649-1893804 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAATCTGAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT217262 WP_000534858.1 NZ_CP083755:86625-86864 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT217262 NZ_CP114128:c1893637-1893579 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References