Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 3621060..3621661 | Replicon | chromosome |
Accession | NZ_CP083754 | ||
Organism | Serratia marcescens strain YL4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A8B4GSJ7 |
Locus tag | LBP97_RS17085 | Protein ID | WP_025304766.1 |
Coordinates | 3621060..3621440 (-) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A8B4GSF3 |
Locus tag | LBP97_RS17090 | Protein ID | WP_025304767.1 |
Coordinates | 3621440..3621661 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LBP97_RS17060 (LBP97_17085) | 3616311..3617587 | + | 1277 | Protein_3349 | DUF3748 domain-containing protein | - |
LBP97_RS17065 (LBP97_17090) | 3617618..3617965 | - | 348 | WP_016929593.1 | YceK/YidQ family lipoprotein | - |
LBP97_RS17070 (LBP97_17095) | 3618275..3618688 | + | 414 | WP_004933919.1 | small heat shock chaperone IbpA | - |
LBP97_RS17075 (LBP97_17100) | 3618795..3619223 | + | 429 | WP_004933922.1 | small heat shock chaperone IbpB | - |
LBP97_RS17080 (LBP97_17105) | 3619391..3621049 | + | 1659 | WP_238968819.1 | putative transporter | - |
LBP97_RS17085 (LBP97_17110) | 3621060..3621440 | - | 381 | WP_025304766.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LBP97_RS17090 (LBP97_17115) | 3621440..3621661 | - | 222 | WP_025304767.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
LBP97_RS17095 (LBP97_17120) | 3621737..3622987 | - | 1251 | WP_238968820.1 | valine--pyruvate transaminase | - |
LBP97_RS17100 (LBP97_17125) | 3623123..3625186 | - | 2064 | WP_238968821.1 | alpha-amylase | - |
LBP97_RS17105 (LBP97_17130) | 3625383..3625535 | + | 153 | WP_162837931.1 | hypothetical protein | - |
LBP97_RS17110 (LBP97_17135) | 3625537..3626514 | - | 978 | WP_049204664.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14241.66 Da Isoelectric Point: 7.3173
>T217259 WP_025304766.1 NZ_CP083754:c3621440-3621060 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL
Download Length: 381 bp
>T217259 NZ_CP114128:998540-998875 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8607.55 Da Isoelectric Point: 4.4915
>AT217259 WP_025304767.1 NZ_CP083754:c3621661-3621440 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE
Download Length: 222 bp
>AT217259 NZ_CP114128:998292-998540 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B4GSJ7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B4GSF3 |