Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2657739..2658408 Replicon chromosome
Accession NZ_CP083754
Organism Serratia marcescens strain YL4

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LBP97_RS12575 Protein ID WP_025304123.1
Coordinates 2657739..2658161 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag LBP97_RS12580 Protein ID WP_004931679.1
Coordinates 2658142..2658408 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBP97_RS12555 (LBP97_12575) 2653627..2654145 + 519 WP_025304119.1 flavodoxin FldB -
LBP97_RS12560 (LBP97_12580) 2654183..2655548 - 1366 Protein_2470 cell envelope integrity protein CreD -
LBP97_RS12565 (LBP97_12585) 2655629..2657047 - 1419 WP_197826902.1 two-component system sensor histidine kinase CreC -
LBP97_RS12570 (LBP97_12590) 2657044..2657739 - 696 WP_025304122.1 two-component system response regulator CreB -
LBP97_RS12575 (LBP97_12595) 2657739..2658161 - 423 WP_025304123.1 protein YgfX Toxin
LBP97_RS12580 (LBP97_12600) 2658142..2658408 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
LBP97_RS12585 (LBP97_12605) 2658729..2659721 + 993 WP_025304124.1 tRNA-modifying protein YgfZ -
LBP97_RS12590 (LBP97_12610) 2659760..2660257 - 498 WP_025304125.1 DUF2165 domain-containing protein -
LBP97_RS12595 (LBP97_12615) 2660408..2661082 - 675 WP_033639467.1 hemolysin III family protein -
LBP97_RS12600 (LBP97_12620) 2661266..2661874 + 609 WP_025304127.1 HD domain-containing protein -
LBP97_RS12605 (LBP97_12625) 2661914..2662840 - 927 WP_025304128.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16525.62 Da        Isoelectric Point: 10.8432

>T217258 WP_025304123.1 NZ_CP083754:c2658161-2657739 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGYGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGNGEEP

Download         Length: 423 bp

>T217258 NZ_CP114128:850985-851392 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT217258 WP_004931679.1 NZ_CP083754:c2658408-2658142 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT217258 NZ_CP114128:850738-851004 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References