Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2295202..2295858 Replicon chromosome
Accession NZ_CP083754
Organism Serratia marcescens strain YL4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LBP97_RS10875 Protein ID WP_238969568.1
Coordinates 2295202..2295591 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag LBP97_RS10880 Protein ID WP_004941563.1
Coordinates 2295595..2295858 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBP97_RS10860 (LBP97_10875) 2291669..2293099 + 1431 WP_049296101.1 MFS transporter -
LBP97_RS10865 (LBP97_10880) 2293096..2294478 + 1383 WP_164063861.1 two-component system sensor histidine kinase BaeS -
LBP97_RS10870 (LBP97_10885) 2294478..2295194 + 717 WP_004941568.1 two-component system response regulator BaeR -
LBP97_RS10875 (LBP97_10890) 2295202..2295591 - 390 WP_238969568.1 type II toxin-antitoxin system VapC family toxin Toxin
LBP97_RS10880 (LBP97_10895) 2295595..2295858 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LBP97_RS10885 (LBP97_10900) 2296196..2296534 + 339 WP_016926703.1 YegP family protein -
LBP97_RS10890 (LBP97_10905) 2296713..2298065 + 1353 WP_025303865.1 tRNA 5-hydroxyuridine modification protein YegQ -
LBP97_RS10895 (LBP97_10910) 2298282..2298503 - 222 WP_141998673.1 hypothetical protein -
LBP97_RS10900 (LBP97_10915) 2298533..2299438 + 906 WP_043137977.1 lipid kinase YegS -
LBP97_RS10905 (LBP97_10920) 2299607..2300821 + 1215 WP_025303867.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14465.81 Da        Isoelectric Point: 9.0823

>T217255 WP_238969568.1 NZ_CP083754:c2295591-2295202 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMIEAFLAAVTVYAWDREAARCYGEM
RANMVRKDKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T217255 NZ_CP114128:308245-308772 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT217255 WP_004941563.1 NZ_CP083754:c2295858-2295595 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT217255 NZ_CP114128:307972-308238 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAACATCGGCGGG
TGATCCTCAATGAGGAATCCTGGATGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References