Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1112394..1112892 Replicon chromosome
Accession NC_008533
Organism Streptococcus pneumoniae D39

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag SPD_RS05785 Protein ID WP_001809704.1
Coordinates 1112394..1112648 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SPD_RS05790 Protein ID WP_000208080.1
Coordinates 1112650..1112892 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPD_RS05780 (SPD_1080) 1110448..1112319 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
SPD_RS05785 (SPD_1081) 1112394..1112648 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPD_RS05790 (SPD_1082) 1112650..1112892 - 243 WP_000208080.1 hypothetical protein Antitoxin
SPD_RS05795 (SPD_1083) 1112983..1113792 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
SPD_RS05800 (SPD_1084) 1113794..1115143 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SPD_RS05805 (SPD_1085) 1115136..1115840 - 705 WP_000722076.1 response regulator transcription factor -
SPD_RS05810 (SPD_1086) 1115895..1117070 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T21725 WP_001809704.1 NC_008533:c1112648-1112394 [Streptococcus pneumoniae D39]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T21725 NC_008533:c1112648-1112394 [Streptococcus pneumoniae D39]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT21725 WP_000208080.1 NC_008533:c1112892-1112650 [Streptococcus pneumoniae D39]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT21725 NC_008533:c1112892-1112650 [Streptococcus pneumoniae D39]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References