Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4833806..4835487 | Replicon | chromosome |
| Accession | NZ_CP083751 | ||
| Organism | Klebsiella pneumoniae strain FAHZZU2591 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A2L0KL13 |
| Locus tag | LBE00_RS23330 | Protein ID | WP_019704723.1 |
| Coordinates | 4833806..4834723 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | LBE00_RS23335 | Protein ID | WP_004177809.1 |
| Coordinates | 4834729..4835487 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LBE00_RS23310 (LBE00_23340) | 4829112..4830632 | + | 1521 | WP_032415851.1 | sugar ABC transporter ATP-binding protein | - |
| LBE00_RS23315 (LBE00_23345) | 4830629..4831627 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| LBE00_RS23320 (LBE00_23350) | 4831658..4832599 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| LBE00_RS23325 (LBE00_23355) | 4832674..4833681 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| LBE00_RS23330 (LBE00_23360) | 4833806..4834723 | - | 918 | WP_019704723.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LBE00_RS23335 (LBE00_23365) | 4834729..4835487 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LBE00_RS23340 (LBE00_23370) | 4835573..4836301 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| LBE00_RS23345 (LBE00_23375) | 4836574..4838721 | + | 2148 | WP_077598990.1 | formate dehydrogenase subunit alpha | - |
| LBE00_RS23350 (LBE00_23380) | 4838951..4839637 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34632.07 Da Isoelectric Point: 5.4707
>T217238 WP_019704723.1 NZ_CP083751:c4834723-4833806 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T217238 NZ_CP114115:c789294-789007 [Pseudomonas sp. GXZC]
ATGACTCAATTTAAAGACTTCGACATAGCTGAGCACCTCAAGACTCCCGAGGACATGGCCGAGTACCTTGAAGCTTCTTT
CGAAGAGGACTCCGGCGACGGCTTGCTGATTCGCTCAGCCCTGAACAACATCGCCCGCGCCCAGGGCATGACCCAAATCG
CCCGCGACGCCGGCCTCGGTCGCGAAAGCCTATACAAAGCCCTCTCCGCCACTGGCAATCCCGAATTCGCGACTATCATG
AAAGTCATGAAAGCGTTGGGCCTGAAGCTTCACGCCACCGCTATCTGA
ATGACTCAATTTAAAGACTTCGACATAGCTGAGCACCTCAAGACTCCCGAGGACATGGCCGAGTACCTTGAAGCTTCTTT
CGAAGAGGACTCCGGCGACGGCTTGCTGATTCGCTCAGCCCTGAACAACATCGCCCGCGCCCAGGGCATGACCCAAATCG
CCCGCGACGCCGGCCTCGGTCGCGAAAGCCTATACAAAGCCCTCTCCGCCACTGGCAATCCCGAATTCGCGACTATCATG
AAAGTCATGAAAGCGTTGGGCCTGAAGCTTCACGCCACCGCTATCTGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT217238 WP_004177809.1 NZ_CP083751:c4835487-4834729 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT217238 NZ_CP114115:c789599-789291 [Pseudomonas sp. GXZC]
ATGATTCGATTCAAGAGATCCGACGAGTTTCAAGAGTGGCTTGATTCGTCACGCAGCAGGCCAGCCCGCGGTCGTGTGTT
GACAAGATTGGATAACGCAACGAGGGGTAACTTCGGAGACTGTGCACCCGTAGGAAATGGCGTATCAGAAATGCGCATCC
ACTATGGCCCTGGATACCGCGTTTACTTCACACGCGTTGACGAGGTGGTTTACCTGTTGTTGATAGGTGGCGATAAATCC
ACGCAAAAACGCGACATCCAGCGCGCTAAAGAAATAGCCGATGAATTTGGAATAAGGAGTGACTCATGA
ATGATTCGATTCAAGAGATCCGACGAGTTTCAAGAGTGGCTTGATTCGTCACGCAGCAGGCCAGCCCGCGGTCGTGTGTT
GACAAGATTGGATAACGCAACGAGGGGTAACTTCGGAGACTGTGCACCCGTAGGAAATGGCGTATCAGAAATGCGCATCC
ACTATGGCCCTGGATACCGCGTTTACTTCACACGCGTTGACGAGGTGGTTTACCTGTTGTTGATAGGTGGCGATAAATCC
ACGCAAAAACGCGACATCCAGCGCGCTAAAGAAATAGCCGATGAATTTGGAATAAGGAGTGACTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L0KL13 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A6TH05 |