Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4677433..4677949 | Replicon | chromosome |
Accession | NZ_CP083751 | ||
Organism | Klebsiella pneumoniae strain FAHZZU2591 |
Toxin (Protein)
Gene name | relE | Uniprot ID | R4YAY3 |
Locus tag | LBE00_RS22535 | Protein ID | WP_004178374.1 |
Coordinates | 4677433..4677717 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | LBE00_RS22540 | Protein ID | WP_002886901.1 |
Coordinates | 4677707..4677949 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LBE00_RS22510 (LBE00_22540) | 4672829..4673092 | - | 264 | WP_004152271.1 | PTS sugar transporter subunit IIB | - |
LBE00_RS22515 (LBE00_22545) | 4673222..4673395 | + | 174 | WP_004222159.1 | hypothetical protein | - |
LBE00_RS22520 (LBE00_22550) | 4673398..4674141 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
LBE00_RS22525 (LBE00_22555) | 4674498..4676636 | + | 2139 | WP_032415880.1 | anaerobic ribonucleoside-triphosphate reductase | - |
LBE00_RS22530 (LBE00_22560) | 4676965..4677429 | + | 465 | WP_004178375.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
LBE00_RS22535 (LBE00_22565) | 4677433..4677717 | - | 285 | WP_004178374.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LBE00_RS22540 (LBE00_22570) | 4677707..4677949 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
LBE00_RS22545 (LBE00_22575) | 4678027..4679937 | - | 1911 | WP_130974884.1 | PRD domain-containing protein | - |
LBE00_RS22550 (LBE00_22580) | 4679960..4681114 | - | 1155 | WP_004178372.1 | lactonase family protein | - |
LBE00_RS22555 (LBE00_22585) | 4681181..4681921 | - | 741 | WP_004186692.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11155.97 Da Isoelectric Point: 10.3787
>T217237 WP_004178374.1 NZ_CP083751:c4677717-4677433 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T217237 NZ_CP114115:361249-361557 [Pseudomonas sp. GXZC]
CTGCTCGTTAAGTGGCGACCTGAGGCTATTTTGGTCTTGACTGAAATTATTGATTTCATTGAGCAGTACAACCCCGTTGC
AGCGGCTTCGCTGCACCGTAACATTGTTGCTGCTACTGAACATTTGTCTTCAATGCCGTATGGATTCAAGCAAGGCCGCT
TGTCAGGTACTCGGGAAATGGTTGTTCATCCAAACTATTTAGTTGTGTATCGCGTGATGGAGCAGGTTGATATTCTGACG
GTACTGCACACACGTCAAGAATACCCCTCGGATGCAATCGTTCCGCTCCACTCGACCTTGCGTCAATAG
CTGCTCGTTAAGTGGCGACCTGAGGCTATTTTGGTCTTGACTGAAATTATTGATTTCATTGAGCAGTACAACCCCGTTGC
AGCGGCTTCGCTGCACCGTAACATTGTTGCTGCTACTGAACATTTGTCTTCAATGCCGTATGGATTCAAGCAAGGCCGCT
TGTCAGGTACTCGGGAAATGGTTGTTCATCCAAACTATTTAGTTGTGTATCGCGTGATGGAGCAGGTTGATATTCTGACG
GTACTGCACACACGTCAAGAATACCCCTCGGATGCAATCGTTCCGCTCCACTCGACCTTGCGTCAATAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT217237 WP_002886901.1 NZ_CP083751:c4677949-4677707 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT217237 NZ_CP114115:361065-361259 [Pseudomonas sp. GXZC]
ATGAGCATCCCACTTTCTCCCATCGTTTCTGAGTTTGAAACTGAAGAGCAGGCTGCCAGCTATGACCGTTGGTTCCGTGC
CAAGGTGCAGGCTTCAATTGATGATCCTCGACCTAGTATTCCGCATGATGAGGCTATGGCTGAGGTTGAGAGGATGTTAG
AAGAGAGGCGCAAGGCTCGCTGGGCTGCTCGTTAA
ATGAGCATCCCACTTTCTCCCATCGTTTCTGAGTTTGAAACTGAAGAGCAGGCTGCCAGCTATGACCGTTGGTTCCGTGC
CAAGGTGCAGGCTTCAATTGATGATCCTCGACCTAGTATTCCGCATGATGAGGCTATGGCTGAGGTTGAGAGGATGTTAG
AAGAGAGGCGCAAGGCTCGCTGGGCTGCTCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A6THG1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |