Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4677433..4677949 Replicon chromosome
Accession NZ_CP083751
Organism Klebsiella pneumoniae strain FAHZZU2591

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LBE00_RS22535 Protein ID WP_004178374.1
Coordinates 4677433..4677717 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LBE00_RS22540 Protein ID WP_002886901.1
Coordinates 4677707..4677949 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBE00_RS22510 (LBE00_22540) 4672829..4673092 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LBE00_RS22515 (LBE00_22545) 4673222..4673395 + 174 WP_004222159.1 hypothetical protein -
LBE00_RS22520 (LBE00_22550) 4673398..4674141 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LBE00_RS22525 (LBE00_22555) 4674498..4676636 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
LBE00_RS22530 (LBE00_22560) 4676965..4677429 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LBE00_RS22535 (LBE00_22565) 4677433..4677717 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LBE00_RS22540 (LBE00_22570) 4677707..4677949 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LBE00_RS22545 (LBE00_22575) 4678027..4679937 - 1911 WP_130974884.1 PRD domain-containing protein -
LBE00_RS22550 (LBE00_22580) 4679960..4681114 - 1155 WP_004178372.1 lactonase family protein -
LBE00_RS22555 (LBE00_22585) 4681181..4681921 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T217237 WP_004178374.1 NZ_CP083751:c4677717-4677433 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T217237 NZ_CP114115:361249-361557 [Pseudomonas sp. GXZC]
CTGCTCGTTAAGTGGCGACCTGAGGCTATTTTGGTCTTGACTGAAATTATTGATTTCATTGAGCAGTACAACCCCGTTGC
AGCGGCTTCGCTGCACCGTAACATTGTTGCTGCTACTGAACATTTGTCTTCAATGCCGTATGGATTCAAGCAAGGCCGCT
TGTCAGGTACTCGGGAAATGGTTGTTCATCCAAACTATTTAGTTGTGTATCGCGTGATGGAGCAGGTTGATATTCTGACG
GTACTGCACACACGTCAAGAATACCCCTCGGATGCAATCGTTCCGCTCCACTCGACCTTGCGTCAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT217237 WP_002886901.1 NZ_CP083751:c4677949-4677707 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT217237 NZ_CP114115:361065-361259 [Pseudomonas sp. GXZC]
ATGAGCATCCCACTTTCTCCCATCGTTTCTGAGTTTGAAACTGAAGAGCAGGCTGCCAGCTATGACCGTTGGTTCCGTGC
CAAGGTGCAGGCTTCAATTGATGATCCTCGACCTAGTATTCCGCATGATGAGGCTATGGCTGAGGTTGAGAGGATGTTAG
AAGAGAGGCGCAAGGCTCGCTGGGCTGCTCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References