Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3956597..3957216 Replicon chromosome
Accession NZ_CP083751
Organism Klebsiella pneumoniae strain FAHZZU2591

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LBE00_RS19145 Protein ID WP_002892050.1
Coordinates 3956998..3957216 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LBE00_RS19140 Protein ID WP_002892066.1
Coordinates 3956597..3956971 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBE00_RS19130 (LBE00_19160) 3951749..3952942 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LBE00_RS19135 (LBE00_19165) 3952965..3956111 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LBE00_RS19140 (LBE00_19170) 3956597..3956971 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LBE00_RS19145 (LBE00_19175) 3956998..3957216 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LBE00_RS19150 (LBE00_19180) 3957375..3957941 + 567 WP_002892030.1 maltose O-acetyltransferase -
LBE00_RS19155 (LBE00_19185) 3957913..3958053 - 141 WP_004147370.1 hypothetical protein -
LBE00_RS19160 (LBE00_19190) 3958074..3958544 + 471 WP_002892026.1 YlaC family protein -
LBE00_RS19165 (LBE00_19195) 3958519..3959970 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LBE00_RS19170 (LBE00_19200) 3960071..3960769 + 699 WP_032414604.1 GNAT family protein -
LBE00_RS19175 (LBE00_19205) 3960766..3960906 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LBE00_RS19180 (LBE00_19210) 3960906..3961169 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217235 WP_002892050.1 NZ_CP083751:3956998-3957216 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T217235 NZ_CP114066:517890-518240 [Bacillus halotolerans]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAGATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT217235 WP_002892066.1 NZ_CP083751:3956597-3956971 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT217235 NZ_CP114066:517604-517885 [Bacillus halotolerans]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAACATTTCTTCCGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References