Detailed information of TA system TA217234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2615333..2616921
• Replicon: chromosome
• Accession: NZ_CP083751
• Organism: Klebsiella pneumoniae strain FAHZZU2591

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LBE00_RS12770
• Protein ID: WP_130974847.1
• Coordinates: 2615333..2616655 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LBE00_RS12775
• Protein ID: WP_004176198.1
• Coordinates: 2616655..2616921 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LBE00_RS12755 (LBE00_12770)	2610389..2612890	+	2502	WP_064153112.1	fimbria/pilus outer membrane usher protein	-
LBE00_RS12760 (LBE00_12775)	2612878..2613882	+	1005	WP_004176196.1	fimbrial protein	-
LBE00_RS12765 (LBE00_12780)	2614024..2615316	+	1293	WP_032414911.1	glycoside hydrolase family 10 protein	-
LBE00_RS12770 (LBE00_12785)	2615333..2616655	-	1323	WP_130974847.1	type II toxin-antitoxin system HipA family toxin	Toxin
LBE00_RS12775 (LBE00_12790)	2616655..2616921	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LBE00_RS12780 (LBE00_12795)	2617308..2617634	-	327	WP_004224757.1	hydroxyisourate hydrolase	-
LBE00_RS12785 (LBE00_12800)	2617631..2618131	-	501	WP_130974846.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LBE00_RS12790 (LBE00_12805)	2618109..2619488	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LBE00_RS12795 (LBE00_12810)	2619834..2620988	+	1155	WP_130974845.1	FAD-dependent urate hydroxylase HpxO	-
LBE00_RS12800 (LBE00_12815)	2620969..2621892	-	924	WP_004184020.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49115.40 Da
• Isoelectric Point: 7.5357

>T217234 WP_130974847.1 NZ_CP083751:c2616655-2615333 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATATTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T217234 NZ_CP114065:4694161-4694472 [Kribbella sp. CA-293567]
ATGCGCCCGTTGCACATCGCGCGGCTGGACAAGCCGCGCCCGGTGGTCGTGCTGACCCGGGAACTGATCCGTCCCCGCCT
CACCAACGTCACGGTGGCCCCGATCACCAGCACCATCCGCGGTCTGTCGACCGAAGTACTGGTCGGCGTCCGGAACGGCC
TGGACCATCCCAGCGCGATCAGCTGCGACAACGTCCAGACCATCCCCAAACTTCAGCTCGGCCGCCTGATCGGCTACCTG
CTGCCCGACCAGGAAGCAGCCCTCGCCGAAGCCATCACCCTCGCCTTCGACCTCGAGGCCGACCTGCTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT217234 WP_004176198.1 NZ_CP083751:c2616921-2616655 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT217234 NZ_CP114065:4693910-4694161 [Kribbella sp. CA-293567]
ATGAGTAAGCAGATCACGGTGCGGTTGCCGGACGAACTGGTGGAGTTCATGGACCGGCTGGTGGATGACAACAAGGCGTC
CAGCCGGGCGTCGGTGGTCGCGCGCGCGATGGAGCGGGAGCGGCGGCGGGAGCTGGCCGAGCGCGACGCGGCCATTCTCG
AGGCGCACAGCCTGGCGGCTCGAGAAGATCCGGACGACCTCGACGGACTGGCGGTCACCGCCGGTGGAACTGTGCTGACC
GATCTCGACTGA