Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781263..781920 Replicon chromosome
Accession NZ_CP083751
Organism Klebsiella pneumoniae strain FAHZZU2591

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LBE00_RS03890 Protein ID WP_002916310.1
Coordinates 781510..781920 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LBE00_RS03885 Protein ID WP_002916312.1
Coordinates 781263..781529 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBE00_RS03860 (LBE00_03865) 776419..777852 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LBE00_RS03865 (LBE00_03870) 777971..778699 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LBE00_RS03870 (LBE00_03875) 778749..779060 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LBE00_RS03875 (LBE00_03880) 779224..779883 + 660 WP_002916317.1 hemolysin III family protein -
LBE00_RS03880 (LBE00_03885) 780034..781017 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LBE00_RS03885 (LBE00_03890) 781263..781529 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LBE00_RS03890 (LBE00_03895) 781510..781920 + 411 WP_002916310.1 protein YgfX Toxin
LBE00_RS03895 (LBE00_03900) 781927..782448 - 522 WP_002916308.1 flavodoxin FldB -
LBE00_RS03900 (LBE00_03905) 782549..783445 + 897 WP_064153067.1 site-specific tyrosine recombinase XerD -
LBE00_RS03905 (LBE00_03910) 783468..784181 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LBE00_RS03910 (LBE00_03915) 784187..785920 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T217225 WP_002916310.1 NZ_CP083751:781510-781920 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T217225 NZ_CP114058:2767015-2767218 [Rouxiella chamberiensis]
ATGAACAAAATTGATTATTTGATGCGTTTGAGAAAGTGCACCACCATTGACACTCTCGAACGCGTTATCGAAAAAAATAA
GTACGAACTTTCCAATGACGAGTTGGAGCTTTTCTATTCAGCTGCCGATCACCGTTTAGCCGAGCTGACGATGAACAAGC
TGTATGACAAGATCCCGACTTCCGTCTGGAAATTCGTTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT217225 WP_002916312.1 NZ_CP083751:781263-781529 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217225 NZ_CP114058:2766603-2766971 [Rouxiella chamberiensis]
ATGGATGAGTACTCGCCTAAGCGACACGATATTGCGCAACTGCGGTTCCTCAACGAAAATTTGTATGACGAAGGAATTGC
GACCTTGGGAGACAGCCATCATGGCTGGGTCAACGACCCGACCTCCGCTGTCAACTTGCAGCTTAATGACCTGATTGAGC
ATATTGCCTCGTTCGTCATGAGCTTTAAAATTAAATACCCGGACGAAACAAACCTCAGCGATCTGGTAGAAGAGTATCTT
GATGATACTTATACCTTATTTAGCAACTACGGAATTAACGATTCTGATTTACGTCAATGGCAAAAAACCAAGAAACGACT
ATTCAGAATGTTCTCAGGGGATTATGTTTGTGCCCTGATGAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References