Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 374466..375441 | Replicon | chromosome |
| Accession | NZ_CP083749 | ||
| Organism | Bacillus sp. CRB-7 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A853XAA8 |
| Locus tag | K8M08_RS01965 | Protein ID | WP_003266839.1 |
| Coordinates | 374704..375441 (-) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A853X9N7 |
| Locus tag | K8M08_RS01960 | Protein ID | WP_000594609.1 |
| Coordinates | 374466..374591 (-) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8M08_RS01935 (K8M08_01935) | 369989..370648 | - | 660 | WP_000682535.1 | CatB-related O-acetyltransferase | - |
| K8M08_RS01940 (K8M08_01940) | 371103..371573 | + | 471 | WP_000771836.1 | DUF5065 family protein | - |
| K8M08_RS01945 (K8M08_01945) | 372116..373585 | - | 1470 | WP_000287531.1 | beta-Ala-His dipeptidase | - |
| K8M08_RS01950 (K8M08_01950) | 373801..374190 | + | 390 | WP_000808872.1 | YxeA family protein | - |
| K8M08_RS01955 (K8M08_01955) | 374214..374390 | - | 177 | WP_000852621.1 | stage II sporulation protein SB | - |
| K8M08_RS01960 (K8M08_01960) | 374466..374591 | - | 126 | WP_000594609.1 | hypothetical protein | Antitoxin |
| K8M08_RS01965 (K8M08_01965) | 374704..375441 | - | 738 | WP_003266839.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| K8M08_RS01970 (K8M08_01970) | 375630..376367 | - | 738 | WP_074619822.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| K8M08_RS01975 (K8M08_01975) | 376534..377016 | - | 483 | WP_000191902.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| K8M08_RS01980 (K8M08_01980) | 377123..378808 | + | 1686 | WP_003266842.1 | alpha-keto acid decarboxylase family protein | - |
| K8M08_RS01985 (K8M08_01985) | 378856..379263 | - | 408 | WP_000072503.1 | VOC family protein | - |
| K8M08_RS01990 (K8M08_01990) | 379383..380093 | - | 711 | WP_000426882.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28361.10 Da Isoelectric Point: 7.9902
>T217220 WP_003266839.1 NZ_CP083749:c375441-374704 [Bacillus sp. CRB-7]
VISNIRIGLFILVIVFLVLVFCYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILVIVFLVLVFCYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T217220 NZ_CP114053:1466908-1467264 [Bifidobacterium longum subsp. infantis]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4892.29 Da Isoelectric Point: 3.9652
>AT217220 WP_000594609.1 NZ_CP083749:c374591-374466 [Bacillus sp. CRB-7]
VIKNNDNDFFKEDNEDTTDFSLIKGDTMQQVEELEDELKRK
VIKNNDNDFFKEDNEDTTDFSLIKGDTMQQVEELEDELKRK
Download Length: 126 bp
>AT217220 NZ_CP114053:1466625-1466921 [Bifidobacterium longum subsp. infantis]
ATGATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCAT
GGGGTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCG
TCCGCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCC
CAGATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA
ATGATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCAT
GGGGTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCG
TCCGCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCC
CAGATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853XAA8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853X9N7 |