Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 330293..330986 | Replicon | plasmid unnamed |
| Accession | NZ_CP083747 | ||
| Organism | Pseudomonas sp. p1(2021b) | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | N2IHR9 |
| Locus tag | K8374_RS26160 | Protein ID | WP_003151133.1 |
| Coordinates | 330609..330986 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | N2IIN5 |
| Locus tag | K8374_RS26155 | Protein ID | WP_001172026.1 |
| Coordinates | 330293..330628 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8374_RS26120 (K8374_26120) | 325841..326533 | + | 693 | WP_023383746.1 | hypothetical protein | - |
| K8374_RS26125 (K8374_26125) | 326570..326977 | + | 408 | WP_023383747.1 | hypothetical protein | - |
| K8374_RS26130 (K8374_26130) | 327751..328620 | - | 870 | WP_223198360.1 | HD-GYP domain-containing protein | - |
| K8374_RS26135 (K8374_26135) | 328712..329059 | - | 348 | WP_263498547.1 | DUF3391 domain-containing protein | - |
| K8374_RS26140 (K8374_26140) | 329216..329596 | - | 381 | WP_001054412.1 | hypothetical protein | - |
| K8374_RS26145 (K8374_26145) | 329593..329919 | - | 327 | WP_000091614.1 | hypothetical protein | - |
| K8374_RS26150 (K8374_26150) | 329943..330278 | - | 336 | WP_000741275.1 | hypothetical protein | - |
| K8374_RS26155 (K8374_26155) | 330293..330628 | - | 336 | WP_001172026.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| K8374_RS26160 (K8374_26160) | 330609..330986 | - | 378 | WP_003151133.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K8374_RS26165 (K8374_26165) | 331385..332227 | - | 843 | WP_049275859.1 | AraC family transcriptional regulator | - |
| K8374_RS26170 (K8374_26170) | 332345..332878 | + | 534 | WP_020309197.1 | carboxymuconolactone decarboxylase family protein | - |
| K8374_RS26175 (K8374_26175) | 332906..333454 | + | 549 | Protein_372 | cytochrome P460 family protein | - |
| K8374_RS26180 (K8374_26180) | 333528..334128 | + | 601 | Protein_373 | uracil-DNA glycosylase family protein | - |
| K8374_RS26185 (K8374_26185) | 334312..335196 | - | 885 | WP_003465017.1 | LysR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..337874 | 337874 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13705.78 Da Isoelectric Point: 9.4693
>T217219 WP_003151133.1 NZ_CP083747:c330986-330609 [Pseudomonas sp. p1(2021b)]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH
Download Length: 378 bp
>T217219 NZ_CP114053:1059249-1059740 [Bifidobacterium longum subsp. infantis]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATGCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAGAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATGCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAGAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12201.39 Da Isoelectric Point: 10.6058
>AT217219 WP_001172026.1 NZ_CP083747:c330628-330293 [Pseudomonas sp. p1(2021b)]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
Download Length: 336 bp
>AT217219 NZ_CP114053:1058887-1059249 [Bifidobacterium longum subsp. infantis]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAGCTTGATACGTATTACAACATGAAGAGGGCCGATTGA
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAGCTTGATACGTATTACAACATGAAGAGGGCCGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A024ELN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A024EKI7 |