Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/PRK09812-ChpS
Location 4273576..4274177 Replicon chromosome
Accession NZ_CP083746
Organism Pseudomonas sp. p1(2021b)

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag K8374_RS19920 Protein ID WP_224456896.1
Coordinates 4273576..4273926 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K8374_RS19925 Protein ID WP_224456897.1
Coordinates 4273923..4274177 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8374_RS19895 (K8374_19895) 4269042..4269527 - 486 WP_084858548.1 peptidylprolyl isomerase -
K8374_RS19900 (K8374_19900) 4269526..4269828 + 303 WP_224459369.1 DUF3565 domain-containing protein -
K8374_RS19905 (K8374_19905) 4269860..4271950 + 2091 WP_224456894.1 phosphate acetyltransferase -
K8374_RS19910 (K8374_19910) 4272094..4272813 - 720 WP_084858551.1 OmpA family protein -
K8374_RS19915 (K8374_19915) 4272909..4273553 - 645 WP_224456895.1 MBL fold metallo-hydrolase -
K8374_RS19920 (K8374_19920) 4273576..4273926 - 351 WP_224456896.1 type II toxin-antitoxin system ChpB family toxin Toxin
K8374_RS19925 (K8374_19925) 4273923..4274177 - 255 WP_224456897.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
K8374_RS19930 (K8374_19930) 4274370..4275062 - 693 WP_224456898.1 HAMP domain-containing sensor histidine kinase -
K8374_RS19935 (K8374_19935) 4275059..4276666 - 1608 WP_224456899.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12362.19 Da        Isoelectric Point: 9.4267

>T217217 WP_224456896.1 NZ_CP083746:c4273926-4273576 [Pseudomonas sp. p1(2021b)]
MRRGRFARGDIVRVCLDPTLGREQQGNSRPALVLTPAAYNASGLAVIVPIIQGGDFARHAGFAVTLSGVGTQTQGVILCN
QLRAVDLEARNAKRIESAPGVVIEDALARVQTLFDH

Download         Length: 351 bp

>T217217 NZ_CP114053:c970319-970035 [Bifidobacterium longum subsp. infantis]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATATGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9160.65 Da        Isoelectric Point: 4.7228

>AT217217 WP_224456897.1 NZ_CP083746:c4274177-4273923 [Pseudomonas sp. p1(2021b)]
MEVKIQQWGNSAAIRLPAAVLKQMQLGVGSILSLDTAGESMVLKPVRAKPKYTLEELIAQCDLDAPEPTELEGWNAMRPA
GREV

Download         Length: 255 bp

>AT217217 NZ_CP114053:c970618-970316 [Bifidobacterium longum subsp. infantis]
ATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGCCCGGCT
CGATGCCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGTTCCACA
CCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAAAGCACC
CAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References