217213

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 259002..259607 Replicon chromosome
Accession NZ_CP083746
Organism Pseudomonas sp. p1(2021b)

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag K8374_RS01150 Protein ID WP_224457638.1
Coordinates 259002..259292 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K8374_RS01155 Protein ID WP_224457639.1
Coordinates 259302..259607 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8374_RS01130 (K8374_01130) 254703..255455 - 753 WP_084856418.1 ABC transporter substrate-binding protein -
K8374_RS01135 (K8374_01135) 255467..256240 - 774 WP_196143925.1 ATP-binding cassette domain-containing protein -
K8374_RS01140 (K8374_01140) 256846..258246 + 1401 WP_224457636.1 GABA permease -
K8374_RS01145 (K8374_01145) 258346..258789 - 444 WP_224457637.1 hypothetical protein -
K8374_RS01150 (K8374_01150) 259002..259292 + 291 WP_224457638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8374_RS01155 (K8374_01155) 259302..259607 + 306 WP_224457639.1 putative addiction module antidote protein Antitoxin
K8374_RS01165 (K8374_01165) 259894..260166 - 273 WP_196143928.1 oxidative damage protection protein -
K8374_RS01170 (K8374_01170) 260163..261230 - 1068 WP_224457640.1 A/G-specific adenine glycosylase -
K8374_RS01175 (K8374_01175) 261227..263476 - 2250 WP_224457641.1 AsmA family protein -
K8374_RS01180 (K8374_01180) 263763..264356 + 594 WP_084856616.1 imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11012.81 Da        Isoelectric Point: 10.2790

>T217213 WP_224457638.1 NZ_CP083746:259002-259292 [Pseudomonas sp. p1(2021b)]
MQTLIQTEVYRRWFAALRDARARARINVRLRRVELGVMGDCKPIDEGVSELRIDYGPGYRVYFVQRGYEVIILLAGGDKA
SQARDIKTALKLARDL

Download         Length: 291 bp

>T217213 NZ_CP114036:c3749434-3749060 [Streptomyces sp. S465]
ATGCACTACCTCACCCTGCCCGAGCTGCTGCACCTCGCCGAGCGCCTCGGGGAGAGCGAAGTGCGCGACTACGGGTTGCT
GGAGTCCGCTCTCGCCCGTCCGCAGGCGAGCGTTTTCGGTCAGGACGCCTACCCGGACGTGTGGCAGAAGGCAGCGGCGC
TGATGGAGTCGCTGGCGCGCAACCATGCCCTGGTGGACGGCAACAAGCGGCTGTCCTGGTACGCGACCTGGGTCTTCCTG
CACATCAACGGGCACCCACTGGACGCGGCCTTCGACGTCGACGAGGCCGAGCGCTTCGTGCTGGGCGTCTGCCAGGGCGA
GCTGGACGTGCCGAAGATCGCGGAGGGGCTGACCCGGTTCACGAACGGAATGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10791.47 Da        Isoelectric Point: 4.7914

>AT217213 WP_224457639.1 NZ_CP083746:259302-259607 [Pseudomonas sp. p1(2021b)]
MTNMKLTKWDAADHLRTEEDMALYLEACLEENDPALLAAALGDIARARGMAQLARDTGLTREGLYKALSADGNPSLATIM
KVMAALGVRLHAELIAPQPAG

Download         Length: 306 bp

>AT217213 NZ_CP114036:c3749631-3749434 [Streptomyces sp. S465]
ATGGCAGCGCTGAATCTACGCTTTACGGACGAAGAGCTCGAGGCCCTGCGCAAGCGCGCCGAGGCGGAGGGCCGGAGCAT
GCAGTCGTTCGCCCACGACGCGGTGATGGCGGCGATCAACGAGCACTCCCGGCTGTTCAACGAGGCCGCGGCCCATGTGT
TGCGGGTGAGCGAAGAGCTCAACCGGAGGCTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References