Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4341732..4342513 | Replicon | chromosome |
| Accession | NZ_CP083731 | ||
| Organism | Salmonella sp. A29-2 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A3G3E5T9 |
| Locus tag | K8W53_RS21190 | Protein ID | WP_000625911.1 |
| Coordinates | 4341732..4342223 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | V7IUD2 |
| Locus tag | K8W53_RS21195 | Protein ID | WP_001271379.1 |
| Coordinates | 4342220..4342513 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8W53_RS21165 (4336868) | 4336868..4339306 | - | 2439 | WP_023224120.1 | F4 (K88) fimbrial usher FaeD | - |
| K8W53_RS21170 (4339316) | 4339316..4339855 | - | 540 | WP_000721295.1 | type 1 fimbrial protein | - |
| K8W53_RS21175 (4339890) | 4339890..4340174 | - | 285 | WP_192917775.1 | PapB/FocB family fimbrial expression transcriptional regulator | - |
| K8W53_RS21180 (4340767) | 4340767..4340994 | + | 228 | WP_001112992.1 | hypothetical protein | - |
| K8W53_RS21185 (4341269) | 4341269..4341517 | - | 249 | Protein_4136 | IS481 family transposase | - |
| K8W53_RS21190 (4341732) | 4341732..4342223 | - | 492 | WP_000625911.1 | GNAT family N-acetyltransferase | Toxin |
| K8W53_RS21195 (4342220) | 4342220..4342513 | - | 294 | WP_001271379.1 | DUF1778 domain-containing protein | Antitoxin |
| K8W53_RS21200 (4342831) | 4342831..4343052 | + | 222 | WP_052939504.1 | hypothetical protein | - |
| K8W53_RS21205 (4343318) | 4343318..4344193 | + | 876 | WP_023205266.1 | AraC family transcriptional regulator | - |
| K8W53_RS21210 (4344190) | 4344190..4344477 | + | 288 | WP_072103482.1 | transcriptional regulator RtsB | - |
| K8W53_RS21215 (4344470) | 4344470..4344652 | - | 183 | WP_072106065.1 | ATP-binding cassette domain-containing protein | - |
| K8W53_RS21220 (4344672) | 4344672..4344771 | + | 100 | Protein_4143 | hypothetical protein | - |
| K8W53_RS21225 (4344819) | 4344819..4345013 | + | 195 | WP_223163373.1 | hypothetical protein | - |
| K8W53_RS21230 (4345308) | 4345308..4346213 | - | 906 | WP_001268192.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | faeI / faeH / faeF / faeE / faeD / faeC | 4329609..4344652 | 15043 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17663.44 Da Isoelectric Point: 7.2655
>T217195 WP_000625911.1 NZ_CP083731:c4342223-4341732 [Salmonella sp. A29-2]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T217195 NZ_CP113974:c3761520-3761110 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTCGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGATCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATTGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGACTGGGTCGTCC
CAATCGTGTAA
ATGCTCAAGTTCATGCTCGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGATCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATTGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGACTGGGTCGTCC
CAATCGTGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10938.54 Da Isoelectric Point: 9.8590
>AT217195 WP_001271379.1 NZ_CP083731:c4342513-4342220 [Salmonella sp. A29-2]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT217195 NZ_CP113974:c3761750-3761520 [Pseudomonas aeruginosa]
ATGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCAGTCGCGCTTCCCGATGACGT
TAAGCGTGTGGATGTGGTCGTTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA
ATGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCAGTCGCGCTTCCCGATGACGT
TAAGCGTGTGGATGTGGTCGTTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3E5T9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V7IUD2 |