Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4341732..4342513 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag K8W53_RS21190 Protein ID WP_000625911.1
Coordinates 4341732..4342223 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag K8W53_RS21195 Protein ID WP_001271379.1
Coordinates 4342220..4342513 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS21165 (4336868) 4336868..4339306 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
K8W53_RS21170 (4339316) 4339316..4339855 - 540 WP_000721295.1 type 1 fimbrial protein -
K8W53_RS21175 (4339890) 4339890..4340174 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
K8W53_RS21180 (4340767) 4340767..4340994 + 228 WP_001112992.1 hypothetical protein -
K8W53_RS21185 (4341269) 4341269..4341517 - 249 Protein_4136 IS481 family transposase -
K8W53_RS21190 (4341732) 4341732..4342223 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
K8W53_RS21195 (4342220) 4342220..4342513 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
K8W53_RS21200 (4342831) 4342831..4343052 + 222 WP_052939504.1 hypothetical protein -
K8W53_RS21205 (4343318) 4343318..4344193 + 876 WP_023205266.1 AraC family transcriptional regulator -
K8W53_RS21210 (4344190) 4344190..4344477 + 288 WP_072103482.1 transcriptional regulator RtsB -
K8W53_RS21215 (4344470) 4344470..4344652 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
K8W53_RS21220 (4344672) 4344672..4344771 + 100 Protein_4143 hypothetical protein -
K8W53_RS21225 (4344819) 4344819..4345013 + 195 WP_223163373.1 hypothetical protein -
K8W53_RS21230 (4345308) 4345308..4346213 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4329609..4344652 15043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T217195 WP_000625911.1 NZ_CP083731:c4342223-4341732 [Salmonella sp. A29-2]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T217195 NZ_CP113974:c3761520-3761110 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTCGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGATCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATTGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGACTGGGTCGTCC
CAATCGTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT217195 WP_001271379.1 NZ_CP083731:c4342513-4342220 [Salmonella sp. A29-2]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT217195 NZ_CP113974:c3761750-3761520 [Pseudomonas aeruginosa]
ATGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCAGTCGCGCTTCCCGATGACGT
TAAGCGTGTGGATGTGGTCGTTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References