Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3989111..3990734 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag K8W53_RS19450 Protein ID WP_000088046.1
Coordinates 3989409..3990734 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag K8W53_RS19445 Protein ID WP_024136327.1
Coordinates 3989111..3989404 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS19415 (3984531) 3984531..3984812 - 282 WP_000710431.1 hypothetical protein -
K8W53_RS19420 (3984878) 3984878..3985333 - 456 WP_224435199.1 hypothetical protein -
K8W53_RS19425 (3985399) 3985399..3986571 + 1173 WP_000952349.1 IS21-like element IS21 family transposase -
K8W53_RS19430 (3986571) 3986571..3987368 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
K8W53_RS19435 (3987407) 3987407..3987742 - 336 WP_065311125.1 hypothetical protein -
K8W53_RS19440 (3988115) 3988115..3988507 + 393 WP_000341066.1 hypothetical protein -
K8W53_RS19445 (3989111) 3989111..3989404 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
K8W53_RS19450 (3989409) 3989409..3990734 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
K8W53_RS19455 (3990795) 3990795..3991001 + 207 WP_000134171.1 hypothetical protein -
K8W53_RS19460 (3991103) 3991103..3991513 + 411 WP_000985911.1 hypothetical protein -
K8W53_RS19465 (3991526) 3991526..3992341 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
K8W53_RS19470 (3992595) 3992595..3992804 + 210 WP_223533973.1 hypothetical protein -
K8W53_RS19480 (3993264) 3993264..3993611 + 348 WP_000609174.1 IS66 family insertion sequence element accessory protein TnpB -
K8W53_RS19485 (3993661) 3993661..3995196 + 1536 WP_001000406.1 IS66 family transposase -
K8W53_RS19490 (3995292) 3995292..3995465 + 174 WP_224435200.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR / blaCTX-M-55 / blaTEM-1B / fosA3 / rmtB / aac(3)-IId / lnu(F) / ant(3'')-Ia / mph(A) / ARR-3 / dfrA14 / aph(3')-Ia - 3930127..3999962 69835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T217193 WP_000088046.1 NZ_CP083731:3989409-3990734 [Salmonella sp. A29-2]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T217193 NZ_CP113974:2033238-2033816 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTACTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT217193 WP_024136327.1 NZ_CP083731:3989111-3989404 [Salmonella sp. A29-2]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT217193 NZ_CP113974:2032595-2033149 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAATCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References