Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3582626..3583846 Replicon chromosome
Accession NC_008463
Organism Pseudomonas aeruginosa UCBPP-PA14

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PA14_RS16305 Protein ID WP_003110488.1
Coordinates 3583268..3583846 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PA14_RS16300 Protein ID WP_003088112.1
Coordinates 3582626..3583180 (+) Length 185 a.a.

Genomic Context

PA14_RS16275PA14_RS16290PA14_RS16295PA14_RS16300PA14_RS16305PA14_RS16280PA14_RS16285PA14_RS16310PA14_RS16315PA14_RS16320
Location: 3578194..3578745 (552 bp)
Type: Others
Protein ID: WP_003139878.1
Location: 3579807..3580268 (462 bp)
Type: Others
Protein ID: WP_003102736.1
Location: 3580273..3582468 (2196 bp)
Type: Others
Protein ID: WP_003139882.1
Location: 3582626..3583180 (555 bp)
Type: Antitoxin
Protein ID: WP_003088112.1
Location: 3583268..3583846 (579 bp)
Type: Toxin
Protein ID: WP_003110488.1
Location: 3578742..3579140 (399 bp)
Type: Others
Protein ID: WP_003088123.1
Location: 3579153..3579476 (324 bp)
Type: Others
Protein ID: WP_003102734.1
Location: 3583955..3585142 (1188 bp)
Type: Others
Protein ID: WP_003139884.1
Location: 3585132..3587303 (2172 bp)
Type: Others
Protein ID: WP_003139887.1
Location: 3587293..3588570 (1278 bp)
Type: Others
Protein ID: WP_003139889.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PA14_RS16275 (PA14_40150)3578194..3578745+552WP_003139878.1XRE family transcriptional regulator-
PA14_RS16280 (PA14_40160)3578742..3579140-399WP_003088123.1NADH-quinone oxidoreductase subunit A-
PA14_RS16285 (PA14_40170)3579153..3579476-324WP_003102734.1multidrug efflux SMR transporter-
PA14_RS16290 (PA14_40180)3579807..3580268+462WP_003102736.1(2Fe-2S)-binding protein-
PA14_RS16295 (PA14_40200)3580273..3582468+2196WP_003139882.1xanthine dehydrogenase family protein molybdopterin-binding subunit-
PA14_RS16300 (PA14_40210)3582626..3583180+555WP_003088112.1helix-turn-helix domain-containing proteinAntitoxin
PA14_RS16305 (PA14_40220)3583268..3583846+579WP_003110488.1HD domain-containing proteinToxin
PA14_RS16310 (PA14_40230)3583955..3585142-1188WP_003139884.1HlyD family efflux transporter periplasmic adaptor subunit-
PA14_RS16315 (PA14_40240)3585132..3587303-2172WP_003139887.1type I secretion system permease/ATPase-
PA14_RS16320 (PA14_40250)3587293..3588570-1278WP_003139889.1TolC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T21719 WP_003110488.1 NC_008463:3583268-3583846 [Pseudomonas aeruginosa UCBPP-PA14]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T21719 NC_008463:3583268-3583846 [Pseudomonas aeruginosa UCBPP-PA14]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCCGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT21719 WP_003088112.1 NC_008463:3582626-3583180 [Pseudomonas aeruginosa UCBPP-PA14]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT21719 NC_008463:3582626-3583180 [Pseudomonas aeruginosa UCBPP-PA14]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCTTGCTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCCCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H2Z8V4

Antitoxin

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Source
ID
Structure
No matching records found

References