Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3400869..3401489 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K8W53_RS16625 Protein ID WP_001280991.1
Coordinates 3401271..3401489 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K8W53_RS16620 Protein ID WP_000344807.1
Coordinates 3400869..3401243 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS16610 (3396008) 3396008..3397201 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K8W53_RS16615 (3397224) 3397224..3400373 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K8W53_RS16620 (3400869) 3400869..3401243 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K8W53_RS16625 (3401271) 3401271..3401489 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K8W53_RS16630 (3401668) 3401668..3402219 + 552 WP_001278793.1 maltose O-acetyltransferase -
K8W53_RS16635 (3402337) 3402337..3402807 + 471 WP_000136183.1 YlaC family protein -
K8W53_RS16640 (3402863) 3402863..3403003 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K8W53_RS16645 (3403009) 3403009..3403269 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K8W53_RS16650 (3403494) 3403494..3405044 + 1551 WP_000213145.1 EAL domain-containing protein -
K8W53_RS16660 (3405275) 3405275..3405664 + 390 WP_023224410.1 MGMT family protein -
K8W53_RS16665 (3405697) 3405697..3406266 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T217189 WP_001280991.1 NZ_CP083731:3401271-3401489 [Salmonella sp. A29-2]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T217189 NZ_CP113973:1418350-1418700 [Paenibacillus polymyxa]
TTGATCGTAAAGCGCGGCGATGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGTCCTACTGTGATCGTAGCGGCCATCACCGCCCAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATT
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTAGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAAATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT217189 WP_000344807.1 NZ_CP083731:3400869-3401243 [Salmonella sp. A29-2]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT217189 NZ_CP113973:1418062-1418343 [Paenibacillus polymyxa]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGC
TATGGAAAATTCCAACCGCAGTGAATTTATCAGGCAGGCCATGAAGCTGTATGTAGGCGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACTTAACCATGGCATCCGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References