Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 833758..834418 | Replicon | chromosome |
Accession | NZ_CP083731 | ||
Organism | Salmonella sp. A29-2 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | Q57K70 |
Locus tag | K8W53_RS04070 | Protein ID | WP_000244756.1 |
Coordinates | 834005..834418 (+) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S5MU13 |
Locus tag | K8W53_RS04065 | Protein ID | WP_000351186.1 |
Coordinates | 833758..834024 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8W53_RS04045 (829687) | 829687..831120 | - | 1434 | WP_001230143.1 | 6-phospho-beta-glucosidase BglA | - |
K8W53_RS04050 (831278) | 831278..831589 | + | 312 | WP_001182976.1 | N(4)-acetylcytidine aminohydrolase | - |
K8W53_RS04055 (831753) | 831753..832412 | + | 660 | WP_000250289.1 | hemolysin III family protein | - |
K8W53_RS04060 (832528) | 832528..833508 | - | 981 | WP_000874178.1 | tRNA-modifying protein YgfZ | - |
K8W53_RS04065 (833758) | 833758..834024 | + | 267 | WP_000351186.1 | FAD assembly factor SdhE | Antitoxin |
K8W53_RS04070 (834005) | 834005..834418 | + | 414 | WP_000244756.1 | protein YgfX | Toxin |
K8W53_RS04075 (834471) | 834471..834992 | - | 522 | WP_001055885.1 | flavodoxin FldB | - |
K8W53_RS04080 (835105) | 835105..836001 | + | 897 | WP_000434302.1 | site-specific tyrosine recombinase XerD | - |
K8W53_RS04085 (836025) | 836025..836738 | + | 714 | WP_023223829.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
K8W53_RS04090 (836744) | 836744..838477 | + | 1734 | WP_023223830.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 16183.15 Da Isoelectric Point: 10.7537
>T217178 WP_000244756.1 NZ_CP083731:834005-834418 [Salmonella sp. A29-2]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
Download Length: 414 bp
>T217178 NZ_CP113951:4009898-4010179 [Rhodococcus sp. JS3073]
GTGATCGAGTCGTTCGCCGACAAAGAGACCGAGCGGGTCTTTCACCGACAGTTCTCGAAGAAGCTCCCGCAGGACATTCA
GCGGATCGCGCGCCGGCGCCTCCTGTTGATCGAGGCTGCCACCGACGTCAACGACCTGAGGGTGCCCCCAGGCAACCGCC
TGGAGAAGCTCTCCGGGGACCGGGTGGGCCAGTACAGCGTTCGGATCAATGATCAGTACCGCATCTGTTTCATCTGGCGC
GCCACCGCCGCATACGACGTGGAGATCACCGACTATCACTAA
GTGATCGAGTCGTTCGCCGACAAAGAGACCGAGCGGGTCTTTCACCGACAGTTCTCGAAGAAGCTCCCGCAGGACATTCA
GCGGATCGCGCGCCGGCGCCTCCTGTTGATCGAGGCTGCCACCGACGTCAACGACCTGAGGGTGCCCCCAGGCAACCGCC
TGGAGAAGCTCTCCGGGGACCGGGTGGGCCAGTACAGCGTTCGGATCAATGATCAGTACCGCATCTGTTTCATCTGGCGC
GCCACCGCCGCATACGACGTGGAGATCACCGACTATCACTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10550.05 Da Isoelectric Point: 6.0783
>AT217178 WP_000351186.1 NZ_CP083731:833758-834024 [Salmonella sp. A29-2]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT217178 NZ_CP113951:4010238-4010531 [Rhodococcus sp. JS3073]
ATGACTACAGACCTGAGCCCAATTCACCCCGGCGAGATCCTCCGCGAGGACTTCCTCGAGCCGTTCGGCATCACGCAGAA
CCGCCTAGCCACGATCATCGGTGTTCCGCCCCGACGGATCAACGAGATCGTGCTCGGCAAGCGGTCGATCACCGCAGACA
CCGCGTTGCGGCTGGCCAAGGCGTTCGGCAACAGTGCGCAGTTCTGGCTCAATATCCAGGACCGCTACGAGCTCGACCTT
GCGGCCGACAAGATAGGCGACGCCCTCGCCAAGATCACGCGTCTCTCGGCATAG
ATGACTACAGACCTGAGCCCAATTCACCCCGGCGAGATCCTCCGCGAGGACTTCCTCGAGCCGTTCGGCATCACGCAGAA
CCGCCTAGCCACGATCATCGGTGTTCCGCCCCGACGGATCAACGAGATCGTGCTCGGCAAGCGGTCGATCACCGCAGACA
CCGCGTTGCGGCTGGCCAAGGCGTTCGGCAACAGTGCGCAGTTCTGGCTCAATATCCAGGACCGCTACGAGCTCGACCTT
GCGGCCGACAAGATAGGCGACGCCCTCGCCAAGATCACGCGTCTCTCGGCATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3Z1E9V5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0YWH4 |