Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833758..834418 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K8W53_RS04070 Protein ID WP_000244756.1
Coordinates 834005..834418 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K8W53_RS04065 Protein ID WP_000351186.1
Coordinates 833758..834024 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS04045 (829687) 829687..831120 - 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -
K8W53_RS04050 (831278) 831278..831589 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K8W53_RS04055 (831753) 831753..832412 + 660 WP_000250289.1 hemolysin III family protein -
K8W53_RS04060 (832528) 832528..833508 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
K8W53_RS04065 (833758) 833758..834024 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K8W53_RS04070 (834005) 834005..834418 + 414 WP_000244756.1 protein YgfX Toxin
K8W53_RS04075 (834471) 834471..834992 - 522 WP_001055885.1 flavodoxin FldB -
K8W53_RS04080 (835105) 835105..836001 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K8W53_RS04085 (836025) 836025..836738 + 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8W53_RS04090 (836744) 836744..838477 + 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T217178 WP_000244756.1 NZ_CP083731:834005-834418 [Salmonella sp. A29-2]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T217178 NZ_CP113951:4009898-4010179 [Rhodococcus sp. JS3073]
GTGATCGAGTCGTTCGCCGACAAAGAGACCGAGCGGGTCTTTCACCGACAGTTCTCGAAGAAGCTCCCGCAGGACATTCA
GCGGATCGCGCGCCGGCGCCTCCTGTTGATCGAGGCTGCCACCGACGTCAACGACCTGAGGGTGCCCCCAGGCAACCGCC
TGGAGAAGCTCTCCGGGGACCGGGTGGGCCAGTACAGCGTTCGGATCAATGATCAGTACCGCATCTGTTTCATCTGGCGC
GCCACCGCCGCATACGACGTGGAGATCACCGACTATCACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT217178 WP_000351186.1 NZ_CP083731:833758-834024 [Salmonella sp. A29-2]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217178 NZ_CP113951:4010238-4010531 [Rhodococcus sp. JS3073]
ATGACTACAGACCTGAGCCCAATTCACCCCGGCGAGATCCTCCGCGAGGACTTCCTCGAGCCGTTCGGCATCACGCAGAA
CCGCCTAGCCACGATCATCGGTGTTCCGCCCCGACGGATCAACGAGATCGTGCTCGGCAAGCGGTCGATCACCGCAGACA
CCGCGTTGCGGCTGGCCAAGGCGTTCGGCAACAGTGCGCAGTTCTGGCTCAATATCCAGGACCGCTACGAGCTCGACCTT
GCGGCCGACAAGATAGGCGACGCCCTCGCCAAGATCACGCGTCTCTCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References