Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 299283..300074 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag K8W53_RS01390 Protein ID WP_000369560.1
Coordinates 299556..300074 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag K8W53_RS01385 Protein ID WP_001275017.1
Coordinates 299283..299552 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS01365 (294864) 294864..295532 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
K8W53_RS01370 (295525) 295525..296580 + 1056 WP_001081707.1 permease-like cell division protein FtsX -
K8W53_RS01375 (296826) 296826..297680 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
K8W53_RS01380 (298002) 298002..299105 + 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
K8W53_RS01385 (299283) 299283..299552 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
K8W53_RS01390 (299556) 299556..300074 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
K8W53_RS01395 (300071) 300071..300454 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
K8W53_RS01400 (300876) 300876..301985 + 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
K8W53_RS01405 (302045) 302045..302971 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K8W53_RS01410 (302968) 302968..304245 + 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
K8W53_RS01415 (304242) 304242..305009 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T217177 WP_000369560.1 NZ_CP083731:299556-300074 [Salmonella sp. A29-2]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T217177 NZ_CP113948:c3258841-3258560 [Flavobacterium praedii]
ATGATAATTTCATTTGGATCAAAAGAAACCGAAAAAATTTGGAATGGAATTGTTGTAAAAAAACCTTCAATAGAAATTCA
ACAAATTTCGAGAAGAAAGCTGAGAATGTTAAACAACTCTCAAGATTTAATAGATTTAAGAATTCCTCCATCGAATCGTT
TAGAAAAATTAAGCGGTAATTTAAAGGAATTTTATAGCATTCTGATTAACAATCAATGGCGCATCATTTTTAATTGGGAA
AATGGAAATGCTTCAAATGTAGAAATTGTAGATTATCATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT217177 WP_001275017.1 NZ_CP083731:299283-299552 [Salmonella sp. A29-2]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT217177 NZ_CP113948:c3258546-3258244 [Flavobacterium praedii]
ATGGAAAAATTAAAAAATATACATCCGGGAGAAATTTTACTTGAAGAATTTCTTGTTCCTTTAGACATAACTCCATATCG
GCTGTCTAAAGAATTGAAAATTCCGCAAACTAGAATTTCAGAAATTGCTAAAGGAAACCGGAGAATTACAGCAGATACAG
CAATACGCTTGAGTCAATATTTTGGAAACTCCCCTAAATTTTGGCTTGGACTACAAGACGATTATGATATAGAGGAAGAA
CAAGAAAACAAAGGGGAAGAAATTCAAGGTATCAAGCCTTTTGATAATCAAAAAGTGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References