Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 195251..196011 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag K8W53_RS00925 Protein ID WP_023225088.1
Coordinates 195526..196011 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag K8W53_RS00920 Protein ID WP_072106018.1
Coordinates 195251..195538 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS00905 (191679) 191679..192107 + 429 Protein_179 IS3 family transposase -
K8W53_RS00910 (192303) 192303..193073 - 771 WP_000456879.1 DUF3800 domain-containing protein -
K8W53_RS00915 (194100) 194100..195128 + 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
K8W53_RS00920 (195251) 195251..195538 + 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
K8W53_RS00925 (195526) 195526..196011 + 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
K8W53_RS00930 (196381) 196381..196920 - 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
K8W53_RS00935 (197093) 197093..197305 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
K8W53_RS00940 (197593) 197593..197883 - 291 WP_000455790.1 HTH-type transcriptional regulator -
K8W53_RS00945 (198322) 198322..199032 + 711 WP_000190524.1 DUF3053 domain-containing protein -
K8W53_RS00950 (199082) 199082..200056 - 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
K8W53_RS00955 (200275) 200275..200937 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - lpfA 192303..206295 13992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T217176 WP_023225088.1 NZ_CP083731:195526-196011 [Salmonella sp. A29-2]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T217176 NZ_CP113946:c1823517-1823236 [Lactobacillus sp. ESL0677]
ATGAGTGATTTTGTCTATAAACCTGCTTTTGAAAGTCAGTTCAAAAAGCATTACAAGAAGATGTTAAAAGGTAGCAAATA
TCAAGCGAAGGATTTTGAGCGAGTTTACCGCAAATTATTATGTAATAAACCGTTAGAAGCAAGATATAATGACTACCCGT
TAATTAACCGTAGACCAGAACGAGACTTACATATCAAGCCAGACTGGTTGCTAATTTATAAATATGATGGTGAGTATGTA
GATTTTATTAATACTGGTTCACGTTCAGATTTATTTAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT217176 WP_072106018.1 NZ_CP083731:195251-195538 [Salmonella sp. A29-2]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp

>AT217176 NZ_CP113946:c1823752-1823510 [Lactobacillus sp. ESL0677]
ATGACGAGTCAAGTGCATTTCAGAATGGATTCTGAAGATAAGGCTAAATTTGAAGTAGTTCTCAAAAACATTGGTTTAAC
ACCAGGCGAGGCCTTTAGAATTTTTGCAAAAAAATCTATTGAAGCTGGAGGCATTCCGTTTGAAGTAACTGAGCCAGCTC
CAGAACTTCAGCGTTCAATTAAGAGTCGTGATTATGTTGACTTTGATGATCCAGAAGCAGGGCTTAAGTGGCTAAATGAG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References