Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2738562..2739076 Replicon chromosome
Accession NZ_CP083728
Organism Staphylococcus aureus strain MR254

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag K9B11_RS13690 Protein ID WP_000581792.1
Coordinates 2738867..2739076 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag K9B11_RS13685 Protein ID WP_000138932.1
Coordinates 2738562..2738855 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9B11_RS13665 (2733825) 2733825..2734466 + 642 WP_000483153.1 thiamine phosphate synthase -
K9B11_RS13670 (2734552) 2734552..2735424 + 873 WP_000725802.1 membrane protein insertase YidC -
K9B11_RS13675 (2736237) 2736237..2736884 - 648 WP_001187629.1 HD domain-containing protein -
K9B11_RS13680 (2736912) 2736912..2738396 - 1485 WP_000571549.1 cardiolipin synthase -
K9B11_RS13685 (2738562) 2738562..2738855 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
K9B11_RS13690 (2738867) 2738867..2739076 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
K9B11_RS13695 (2739204) 2739204..2739341 + 138 WP_000828354.1 Lmo0850 family protein -
K9B11_RS13700 (2739605) 2739605..2740807 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K9B11_RS13705 (2741125) 2741125..2742195 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
K9B11_RS13710 (2742210) 2742210..2743568 + 1359 WP_224433968.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T217174 WP_000581792.1 NZ_CP083728:2738867-2739076 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T217174 NZ_CP113945:1103247-1103519 [Lactobacillus sp. ESL0680]
ATGTTAAATATTAAGGTTACAGCTAAGTTTAGAAAAGACGTCAAGCGGTGTAATAGGCAAGGGCTACCAATGACGCAACT
TAAGTTAGTTATTCATGAACTTGAACAAAATCACGTCCTGTCCTCTAATTATAAAAATCATGCTTTAGATGGAACTTACT
CTAATTATCTTGAATGCCATATAAAGCCAGATTGGTTGTTAATCTATCAAATTACTCAAATAACTTTGGCTCTTATTAGA
ACAGGTAGTCATGCAGAATTATTTAAAAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT217174 WP_000138932.1 NZ_CP083728:2738562-2738855 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT217174 NZ_CP113945:1102986-1103243 [Lactobacillus sp. ESL0680]
ATGAATAAAACTTTACAGGCCCGAATGGATGGTAAACTTATGGATGAAGCAGAAGGTATCTTAAAAGATTTAGGACTTAA
TCGTTCAACTGCCTTGAAAATTTTTTATCAACAAATTGTCTGGAATAATGGTTTACCTTTTGCAGTAAAAAAACCTGAAA
TCCTAAATGAAGAAACGTTGGATGCTATGCATGAAGATTTGTCTAAGACCAAGACTTACGATAATTCGGATGAATTATGG
CATGACTTGGGTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References