Detailed information of TA system TA021717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 278606..279531
• Replicon: chromosome
• Accession: NC_008463
• Organism: Pseudomonas aeruginosa UCBPP-PA14

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: PA14_RS01275
• Protein ID: WP_170868735.1
• Coordinates: 279205..279531 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: PA14_RS01270
• Protein ID: WP_003111464.1
• Coordinates: 278606..279133 (+)
• Length: 176 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PA14_RS01245 (PA14_03110)	273633..273920	-	288	WP_003137130.1	hypothetical protein	-
PA14_RS01250 (PA14_03120)	274012..274488	-	477	WP_003118626.1	MarR family transcriptional regulator	-
PA14_RS01255 (PA14_03130)	274529..276019	-	1491	WP_003137133.1	UbiD family decarboxylase	-
PA14_RS01260 (PA14_03150)	276153..276839	-	687	WP_003106170.1	DUF1275 domain-containing protein	-
PA14_RS01265 (PA14_03160)	277003..277935	-	933	WP_003084116.1	hypothetical protein	-
PA14_RS01270 (PA14_03163)	278606..279133	+	528	WP_003111464.1	SocA family protein	Antitoxin
PA14_RS01275 (PA14_03166)	279205..279531	+	327	WP_170868735.1	hypothetical protein	Toxin
PA14_RS29980 (PA14_03190)	280973..282415	-	1443	WP_003133043.1	DUF2875 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (18-128)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12385.38 Da
• Isoelectric Point: 9.1081

>T21717 WP_170868735.1 NC_008463:279205-279531 [Pseudomonas aeruginosa UCBPP-PA14]
MNDPVYCPVLGYDAVLLVNISTVYPDKYFDQSCILKKGCHPFVLRDSWVVYREAGPFNLARLEQGVAQKSIKTHQPINAG
DFTRIRAGFDISPDVKIKVERFMRQHKI

Nucleotide

• Length: 327 bp

>T21717 NC_008463:279205-279531 [Pseudomonas aeruginosa UCBPP-PA14]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCGCGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin

Protein

• Length: 176 a.a.
• Molecular weight: 20237.82 Da
• Isoelectric Point: 5.7215

>AT21717 WP_003111464.1 NC_008463:278606-279133 [Pseudomonas aeruginosa UCBPP-PA14]
MAAFFLASAEGPLPHLTLIKLLYLADRESMARFDVPMSDDRAVSMPHGPVLSSTLDLIKGRLRSEVWSAWISPLVDHEVR
LVHDVENWDDLDELSRSDRSILESVWQEFGHMTKYQLRDYTHHHIGEWHDPHGSSRDIDPKDTFMALGQSEELAEIKARD
LAERRRHGRKLSEFI

Nucleotide

• Length: 528 bp

>AT21717 NC_008463:278606-279133 [Pseudomonas aeruginosa UCBPP-PA14]
ATGGCAGCTTTCTTTTTGGCGAGTGCCGAAGGGCCGCTGCCTCATCTCACGCTGATCAAACTGCTGTACCTGGCAGACCG
AGAGTCGATGGCTCGTTTCGACGTTCCCATGTCGGACGATCGAGCTGTTTCCATGCCCCATGGGCCTGTCCTTTCCTCGA
CGCTAGACCTCATCAAGGGGCGTTTGCGCTCTGAGGTTTGGAGCGCTTGGATTTCTCCGTTGGTGGATCACGAGGTCCGT
CTGGTCCATGACGTGGAGAATTGGGACGATCTGGATGAGTTGAGCCGATCGGATCGCAGCATTTTGGAATCGGTCTGGCA
AGAGTTTGGCCACATGACCAAGTACCAATTGCGGGACTACACCCACCATCACATTGGTGAGTGGCACGACCCCCACGGCT
CTTCCAGGGACATTGATCCAAAGGATACTTTCATGGCGCTTGGTCAAAGCGAGGAGCTGGCGGAGATCAAGGCGCGCGAT
CTTGCTGAGCGCCGTCGGCACGGTAGGAAGCTGTCTGAGTTCATTTGA