Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1212428..1212905 Replicon chromosome
Accession NZ_CP083728
Organism Staphylococcus aureus strain MR254

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag K9B11_RS06165 Protein ID WP_000052078.1
Coordinates 1212717..1212905 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K9B11_RS06160 Protein ID WP_001059690.1
Coordinates 1212428..1212688 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9B11_RS06125 (1207821) 1207821..1208537 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
K9B11_RS06130 (1208685) 1208685..1209107 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
K9B11_RS06135 (1209506) 1209506..1210000 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
K9B11_RS06140 (1210155) 1210155..1210772 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
K9B11_RS06145 (1210845) 1210845..1211426 - 582 WP_001140693.1 histidine phosphatase family protein -
K9B11_RS06150 (1211651) 1211651..1211887 + 237 WP_000368687.1 hypothetical protein -
K9B11_RS06155 (1211884) 1211884..1212087 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
K9B11_RS06160 (1212428) 1212428..1212688 + 261 WP_001059690.1 hypothetical protein Antitoxin
K9B11_RS06165 (1212717) 1212717..1212905 + 189 WP_000052078.1 hypothetical protein Toxin
K9B11_RS06170 (1213093) 1213093..1213662 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
K9B11_RS06175 (1213750) 1213750..1214034 + 285 WP_001004395.1 hypothetical protein -
K9B11_RS06180 (1214096) 1214096..1214314 + 219 WP_000005886.1 hypothetical protein -
K9B11_RS06185 (1214810) 1214810..1215010 - 201 WP_001059082.1 cold-shock protein -
K9B11_RS06190 (1215367) 1215367..1216053 - 687 WP_001548082.1 thermonuclease family protein -
K9B11_RS06195 (1216394) 1216394..1216864 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-60)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T217165 WP_000052078.1 NZ_CP083728:1212717-1212905 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T217165 NZ_CP113939:857414-857908 [Bifidobacterium sp. ESL0690]
ATGAAGGAAAGCAAACGCAATATTGTATTTGATACCAATATCCTTATCGATATCGTTATGCATCGTTCATTGCGGGAGTC
CGCAGCGTTAAAGCTCATGGACGTATGTGCCAATCAGACTTTAAATCCTATGTGCGTGGCATTGTCGCTCAAAGATGTTG
ATTACATTGTGAAAGTGAACACCAAACGGGATTTCAAAGATGCCATGGCAGGCGTTGAGCAGGCCACGGTGCAGCAGCTT
GTTGCTCAGGTTGGCTGGAACAGTGTTGAATCAATCATGGAGGTTTGTGAGGTCGTTGCTGTTGATGGTCAAGTTTGCAA
AAATGCGCTGAAATTGCGTTCTGCACATCCTGATTATGAGGACGACCTCATTATCGCCGCGTCGCGCCAGGCTAATGCCG
ACATGGTGGTGACCGGCGACCAGGATTTGATCAAGCATTTTCCGGATTTGTGCGTCAGCGTCGAGGATGCGCTGAAACAG
ATTGAAGAAGACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT217165 WP_001059690.1 NZ_CP083728:1212428-1212688 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT217165 NZ_CP113939:857052-857417 [Bifidobacterium sp. ESL0690]
ATGTCGATGGTGCAGATGAACGTTCGTATCGATGCCGACTTGAAAGACGAGGTCGACGAGATACTGAAGCGTATTGGCAA
GACTCCGAGTTCCGTGATCCGCGAGCTGTGGGACTACATCCAGGATTCTGGCGAGATTCCCGATTTGGAAACGGCTCGCG
AGAAAAAGGATCAGGAGCTCGAAAAACGAAAGAAACTTGAGAAGATCGACAATATGAGCGGAATAGTCCCGCGAACTTTG
AGCGATATGGGACTTATCGGGCGTGGCGATGATCCGTTCAAGTCGATGTCTGCAAAGGAACTTCATGATTATGCGGACGA
ACAACGGTATGAGGATTACATTCAAGAAAGCGTGGCAGTACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References