Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 3384192..3384812 | Replicon | chromosome |
| Accession | NZ_CP083709 | ||
| Organism | Enterobacter cloacae complex sp. ECL352 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | A0A1H8SI38 |
| Locus tag | LBF07_RS16435 | Protein ID | WP_008499287.1 |
| Coordinates | 3384192..3384410 (-) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | V3PBI9 |
| Locus tag | LBF07_RS16440 | Protein ID | WP_008499288.1 |
| Coordinates | 3384438..3384812 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LBF07_RS16405 (LBF07_16405) | 3380206..3380466 | + | 261 | WP_045356432.1 | type B 50S ribosomal protein L31 | - |
| LBF07_RS16410 (LBF07_16410) | 3380469..3380609 | + | 141 | WP_003859006.1 | type B 50S ribosomal protein L36 | - |
| LBF07_RS16415 (LBF07_16415) | 3380606..3381316 | - | 711 | WP_087822105.1 | GNAT family protein | - |
| LBF07_RS16420 (LBF07_16420) | 3381418..3382878 | + | 1461 | WP_094934746.1 | PLP-dependent aminotransferase family protein | - |
| LBF07_RS16425 (LBF07_16425) | 3382850..3383317 | - | 468 | WP_045400719.1 | YlaC family protein | - |
| LBF07_RS16430 (LBF07_16430) | 3383435..3383986 | - | 552 | WP_047061252.1 | maltose O-acetyltransferase | - |
| LBF07_RS16435 (LBF07_16435) | 3384192..3384410 | - | 219 | WP_008499287.1 | HHA domain-containing protein | Toxin |
| LBF07_RS16440 (LBF07_16440) | 3384438..3384812 | - | 375 | WP_008499288.1 | Hha toxicity modulator TomB | Antitoxin |
| LBF07_RS16445 (LBF07_16445) | 3385324..3388470 | - | 3147 | WP_029741964.1 | multidrug efflux RND transporter permease subunit AcrB | - |
| LBF07_RS16450 (LBF07_16450) | 3388493..3389686 | - | 1194 | WP_029741963.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8612.00 Da Isoelectric Point: 8.9008
>T217151 WP_008499287.1 NZ_CP083709:c3384410-3384192 [Enterobacter cloacae complex sp. ECL352]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR
Download Length: 219 bp
>T217151 NZ_CP113918:822031-822528 [Bifidobacterium sp. ESL0769]
ATGATTGAAGAAAAACGAGTGGTTTTCGACACGAATGTGTTGCTGGATTACCTTCTTGGCTGGCGTTCTGGTAACGCGAA
CGCTATACAACTTCTACGTGTCTGTTTGGATTCGGACGTGATTAAACTCCTTTGCATATCCTTGTCTTTAAAAGATGTTG
ACTACATTTCGAGGTCATCGTTTAAAAAACAATTTGCAAACAGTGAATCTGTAGTTGTGCAGGCTACGGTCTCCAATATG
GCTCCTAAGTTCGGTTGGCATTGTGTTGATGATTTATTGAAAATAATTGCGATGGTGGTTGCAGTCGACCAAGTGACTTG
CAAGAATGCTCTCAAGCTATGGGAGGTTCATCCTGATTATGAGGACGACCTCATTATCGCCGCGTCACGCCAGGCCAACG
CCGACATGGTGGTGACGGGCGACCAGGATTTGATCAAGCATTTTCCGGATCTATGCGTTAGCGTCGAGGACGCGCTGAAA
CAGATTGAAGAAGACTGA
ATGATTGAAGAAAAACGAGTGGTTTTCGACACGAATGTGTTGCTGGATTACCTTCTTGGCTGGCGTTCTGGTAACGCGAA
CGCTATACAACTTCTACGTGTCTGTTTGGATTCGGACGTGATTAAACTCCTTTGCATATCCTTGTCTTTAAAAGATGTTG
ACTACATTTCGAGGTCATCGTTTAAAAAACAATTTGCAAACAGTGAATCTGTAGTTGTGCAGGCTACGGTCTCCAATATG
GCTCCTAAGTTCGGTTGGCATTGTGTTGATGATTTATTGAAAATAATTGCGATGGTGGTTGCAGTCGACCAAGTGACTTG
CAAGAATGCTCTCAAGCTATGGGAGGTTCATCCTGATTATGAGGACGACCTCATTATCGCCGCGTCACGCCAGGCCAACG
CCGACATGGTGGTGACGGGCGACCAGGATTTGATCAAGCATTTTCCGGATCTATGCGTTAGCGTCGAGGACGCGCTGAAA
CAGATTGAAGAAGACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14481.28 Da Isoelectric Point: 4.8886
>AT217151 WP_008499288.1 NZ_CP083709:c3384812-3384438 [Enterobacter cloacae complex sp. ECL352]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC
Download Length: 375 bp
>AT217151 NZ_CP113918:821644-822018 [Bifidobacterium sp. ESL0769]
ATGGGTGCGGTGAAGGAGATTGTTATGTCGATGGTGCAGATGAATGTTCGTATCGATTCTGACGTGAAGGATGATGTCGA
CGAGATACTCAAGCGCAAGGGGAAGAACCCAAGTTCCGTGGTGCGTGAACTGTGGGACTTCATCAGGGATTCTGGCGATA
CTCCGGATTTGCGGACTAAAGCTGAAAAGGCTAATAAAGAAGCCGAAAAGCAACGCAGGCTTAAGGCGATAGAGGATGGT
GCGACTTTATGGTCTCGAACGTTGAAAGAAGCTGGTTTGTCTGATGACGGCCAGCATCCTTGGGCGAATATGTCGTATAA
GGAAATGCGTGACGCTGCCTATGAAGATGTAGTCGATGAATATGCACATAAATGA
ATGGGTGCGGTGAAGGAGATTGTTATGTCGATGGTGCAGATGAATGTTCGTATCGATTCTGACGTGAAGGATGATGTCGA
CGAGATACTCAAGCGCAAGGGGAAGAACCCAAGTTCCGTGGTGCGTGAACTGTGGGACTTCATCAGGGATTCTGGCGATA
CTCCGGATTTGCGGACTAAAGCTGAAAAGGCTAATAAAGAAGCCGAAAAGCAACGCAGGCTTAAGGCGATAGAGGATGGT
GCGACTTTATGGTCTCGAACGTTGAAAGAAGCTGGTTTGTCTGATGACGGCCAGCATCCTTGGGCGAATATGTCGTATAA
GGAAATGCGTGACGCTGCCTATGAAGATGTAGTCGATGAATATGCACATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1H8SI38 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V3PBI9 |