Detailed information of TA system TA021715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 643157..643691
• Replicon: chromosome
• Accession: NC_008392
• Organism: Burkholderia ambifaria AMMD

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q0B2J5
• Locus tag: BAMB_RS30345
• Protein ID: WP_011660961.1
• Coordinates: 643392..643691 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q0B2J6
• Locus tag: BAMB_RS30340
• Protein ID: WP_011660960.1
• Coordinates: 643157..643402 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMB_RS30315	638421..639146	-	726	WP_006750591.1	pirin family protein	-
BAMB_RS30320	639274..640158	+	885	WP_011660956.1	LysR family transcriptional regulator	-
BAMB_RS30325	640361..641386	+	1026	WP_011660957.1	DUF1311 domain-containing protein	-
BAMB_RS30330	641628..642086	+	459	WP_011660958.1	MEKHLA domain-containing protein	-
BAMB_RS30335	642355..642837	+	483	WP_011660959.1	hypothetical protein	-
BAMB_RS30340	643157..643402	+	246	WP_011660960.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BAMB_RS30345	643392..643691	+	300	WP_011660961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAMB_RS30355	644202..644615	+	414	WP_011660963.1	DoxX family protein	-
BAMB_RS30360	644777..645721	+	945	WP_041491790.1	SDR family oxidoreductase	-
BAMB_RS30365	646162..647511	+	1350	WP_041491791.1	reverse transcriptase family protein	-
BAMB_RS30370	647880..648209	+	330	WP_006750598.1	H-NS histone family protein	-
BAMB_RS30375	648402..648656	+	255	Protein_531	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11821.36 Da
• Isoelectric Point: 6.4862

>T21715 WP_011660961.1 NC_008392:643392-643691 [Burkholderia ambifaria AMMD]
MPIEARLVRLTPLAEADLEDIWTYTFERWSLEQAEHYVGELASAFERLARREWRGRPSRAGNGYWRYMVGSHVVFYRETA
DSLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T21715 NC_008392:643392-643691 [Burkholderia ambifaria AMMD]
ATGCCGATTGAGGCGCGTCTGGTGCGGCTGACGCCGCTGGCCGAGGCCGATCTCGAGGACATCTGGACCTACACCTTCGA
ACGCTGGTCGCTTGAGCAGGCCGAGCACTATGTGGGCGAGCTCGCCTCGGCGTTCGAGCGTCTCGCGCGGCGCGAGTGGA
GAGGGCGACCGAGTCGTGCGGGCAACGGCTATTGGCGCTACATGGTCGGTTCCCACGTGGTGTTCTATCGGGAAACGGCC
GACAGCCTTGACGTGATTCGGGTATTGCATCAACGCATGGACGTGGACCGGCACCTGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8806.80 Da
• Isoelectric Point: 5.6726

>AT21715 WP_011660960.1 NC_008392:643157-643402 [Burkholderia ambifaria AMMD]
MARNTSISLGDHLAQFVDTQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGEPTAFDSQAFLERMRKKHA
D

Nucleotide

• Length: 246 bp

>AT21715 NC_008392:643157-643402 [Burkholderia ambifaria AMMD]
ATGGCACGGAACACTTCAATCTCGCTGGGAGACCACCTCGCTCAGTTTGTCGACACGCAGGTCGCATCCGGTCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGCCTGCTCGAAACGCAGGAAACCGAGTTGCGGGCCCTGCAGGAGGCCT
TGAAGGCCGGCGAGGCCTCGGGCGAGCCGACTGCCTTTGACAGCCAGGCGTTCTTGGAGCGGATGCGGAAAAAGCATGCC
GATTGA

Structures

Toxin

• AlphaFold DB: Q0B2J5

Antitoxin

• AlphaFold DB: Q0B2J6