Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 1652531..1653210 | Replicon | chromosome |
| Accession | NZ_CP083709 | ||
| Organism | Enterobacter cloacae complex sp. ECL352 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A411GL63 |
| Locus tag | LBF07_RS08030 | Protein ID | WP_016243829.1 |
| Coordinates | 1652531..1652872 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A8B2XJW9 |
| Locus tag | LBF07_RS08035 | Protein ID | WP_016243830.1 |
| Coordinates | 1652893..1653210 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LBF07_RS08010 (LBF07_08010) | 1647808..1649611 | + | 1804 | Protein_1560 | DNA primase | - |
| LBF07_RS08015 (LBF07_08015) | 1649707..1651554 | + | 1848 | WP_023309228.1 | RNA polymerase sigma factor RpoD | - |
| LBF07_RS08020 (LBF07_08020) | 1651662..1652168 | - | 507 | WP_029741755.1 | G/U mismatch-specific DNA glycosylase | - |
| LBF07_RS08030 (LBF07_08030) | 1652531..1652872 | - | 342 | WP_016243829.1 | TA system toxin CbtA family protein | Toxin |
| LBF07_RS08035 (LBF07_08035) | 1652893..1653210 | - | 318 | WP_016243830.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LBF07_RS08040 (LBF07_08040) | 1653231..1653452 | - | 222 | WP_007777714.1 | DUF987 domain-containing protein | - |
| LBF07_RS08045 (LBF07_08045) | 1653461..1653937 | - | 477 | WP_016243831.1 | RadC family protein | - |
| LBF07_RS08050 (LBF07_08050) | 1653953..1654414 | - | 462 | WP_224435139.1 | antirestriction protein | - |
| LBF07_RS08060 (LBF07_08060) | 1654892..1655794 | - | 903 | WP_221929554.1 | transcriptional regulator GcvA | - |
| LBF07_RS08065 (LBF07_08065) | 1655910..1656242 | + | 333 | WP_111975974.1 | gamma-glutamylcyclotransferase family protein | - |
| LBF07_RS08070 (LBF07_08070) | 1656310..1657242 | + | 933 | WP_111975975.1 | DMT family transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13020.04 Da Isoelectric Point: 9.9961
>T217148 WP_016243829.1 NZ_CP083709:c1652872-1652531 [Enterobacter cloacae complex sp. ECL352]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR
Download Length: 342 bp
>T217148 NZ_CP113917:c1596892-1596395 [Bifidobacterium sp. ESL0775]
ATGATTGAAGAAAAACGAGTGGTTTTCGACACGAATGTGTTGCTGGATTACCTTCTTGGATGGCGTTCCGGTAACGCGAA
CGCTATGCAACTTCTGCGTGCCTGTTTGGATTCGGACGTGATTAAGCTGCTTTGCATATCCTTGTCTTTAAAGGATGTTG
ACTACATTTCGAGGTCATCGTTCAAAAAACAATTTGCAAACAGCGAATCTGTAGTTGTGCAGGCTACGGTCTCCAATATG
GCTCCTAAATTCGGTTGGCATTGCGTTGATGATTTATTGAAATTAATTGCAATGGTGGTTGCGGTTGATCAATCAACTTG
CAAGAATGCTCTCAAGCTATGGGAGGTTCATCCCGATTATGAGGATGACCTCATTATCGCCGCGTCGCGCCAGGCCAACG
CCGACATGGTGGTGACCGGTGACCAGGATCTGATCAAGCATTTTCCGGATTTGTGCGTCAGCGTCGAGGACGCACTGAAG
CAGATTGAAGAGGACTGA
ATGATTGAAGAAAAACGAGTGGTTTTCGACACGAATGTGTTGCTGGATTACCTTCTTGGATGGCGTTCCGGTAACGCGAA
CGCTATGCAACTTCTGCGTGCCTGTTTGGATTCGGACGTGATTAAGCTGCTTTGCATATCCTTGTCTTTAAAGGATGTTG
ACTACATTTCGAGGTCATCGTTCAAAAAACAATTTGCAAACAGCGAATCTGTAGTTGTGCAGGCTACGGTCTCCAATATG
GCTCCTAAATTCGGTTGGCATTGCGTTGATGATTTATTGAAATTAATTGCAATGGTGGTTGCGGTTGATCAATCAACTTG
CAAGAATGCTCTCAAGCTATGGGAGGTTCATCCCGATTATGAGGATGACCTCATTATCGCCGCGTCGCGCCAGGCCAACG
CCGACATGGTGGTGACCGGTGACCAGGATCTGATCAAGCATTTTCCGGATTTGTGCGTCAGCGTCGAGGACGCACTGAAG
CAGATTGAAGAGGACTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12041.72 Da Isoelectric Point: 7.7518
>AT217148 WP_016243830.1 NZ_CP083709:c1653210-1652893 [Enterobacter cloacae complex sp. ECL352]
MTHITWGLQRNITPRLGARLVQEGNRMHYLADRASITGKFSDTECRKLDETFPHFIRQMESMLTTGEMNPRNAHCVTLFH
NGFTCEADTLGSCGYVYIAIYPTQR
MTHITWGLQRNITPRLGARLVQEGNRMHYLADRASITGKFSDTECRKLDETFPHFIRQMESMLTTGEMNPRNAHCVTLFH
NGFTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT217148 NZ_CP113917:c1597257-1596907 [Bifidobacterium sp. ESL0775]
ATGTCGATGGTGCAGATGAACGTTCGTATCGATGCCGACTTAAAAGACGACGTTGACGAGATACTCAAGCGCAGGGGGAA
GAACCCAAGTTCCGTGGTGCGTGAGCTGTGGGACTTCATCAAGGATTATGGCGATACTCCGGATTTGCAAACTAAAGCTG
AAAAGGCCGATAGGGAAGCCGAAAAGCAGCGCAGACTCAAGGCGATGGAGGATGGTGCGACCTTGTGGTCTCGAACGTTG
AAAGAGGCTGGTTTGTCTGATGACGGCGAACATCCTTGGGCGAATATGACATATAAGGAAATGCGCGATGCGGCTTATGA
AGATGTAGTCGATGAATATGCGCATAAATAA
ATGTCGATGGTGCAGATGAACGTTCGTATCGATGCCGACTTAAAAGACGACGTTGACGAGATACTCAAGCGCAGGGGGAA
GAACCCAAGTTCCGTGGTGCGTGAGCTGTGGGACTTCATCAAGGATTATGGCGATACTCCGGATTTGCAAACTAAAGCTG
AAAAGGCCGATAGGGAAGCCGAAAAGCAGCGCAGACTCAAGGCGATGGAGGATGGTGCGACCTTGTGGTCTCGAACGTTG
AAAGAGGCTGGTTTGTCTGATGACGGCGAACATCCTTGGGCGAATATGACATATAAGGAAATGCGCGATGCGGCTTATGA
AGATGTAGTCGATGAATATGCGCATAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A411GL63 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B2XJW9 |