Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1495351..1496008 Replicon chromosome
Accession NZ_CP083709
Organism Enterobacter cloacae complex sp. ECL352

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag LBF07_RS07245 Protein ID WP_021242050.1
Coordinates 1495351..1495761 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LBF07_RS07250 Protein ID WP_010435322.1
Coordinates 1495742..1496008 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBF07_RS07225 (LBF07_07225) 1491344..1493077 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
LBF07_RS07230 (LBF07_07230) 1493083..1493796 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LBF07_RS07235 (LBF07_07235) 1493825..1494721 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
LBF07_RS07240 (LBF07_07240) 1494823..1495344 + 522 WP_064673272.1 flavodoxin FldB -
LBF07_RS07245 (LBF07_07245) 1495351..1495761 - 411 WP_021242050.1 protein YgfX Toxin
LBF07_RS07250 (LBF07_07250) 1495742..1496008 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LBF07_RS07255 (LBF07_07255) 1496303..1497283 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
LBF07_RS07260 (LBF07_07260) 1497358..1498017 - 660 WP_033146591.1 hemolysin III family protein -
LBF07_RS07265 (LBF07_07265) 1498183..1498494 - 312 WP_094935379.1 N(4)-acetylcytidine aminohydrolase -
LBF07_RS07270 (LBF07_07270) 1498546..1499277 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
LBF07_RS07275 (LBF07_07275) 1499394..1500827 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T217147 WP_021242050.1 NZ_CP083709:c1495761-1495351 [Enterobacter cloacae complex sp. ECL352]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T217147 NZ_CP113917:c368910-368611 [Bifidobacterium sp. ESL0775]
ATGAGTTACGGAATGCTTAGCCACATCAAACGAACCGGGACATTCCTCAAGGATGTCAAACGACTCAAGCGGAAACATTT
TGACCTCGACAAGCTCGATTATGTCATCAAACTGTTGATGGACCAGGACACCGTCACTCTGATCCATCAATATGATGACC
ATGCTCTAAAAGGCAACCTCCACACATTGCGCGAACTCCATATACAGCCCGATTGGCTTCTGGTATATCAAATCGAGCAT
GGTACATTAACACTCGTTCTCGTAGAAACAGGTAGCCACAAGCAGTTGCTAGGCAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT217147 WP_010435322.1 NZ_CP083709:c1496008-1495742 [Enterobacter cloacae complex sp. ECL352]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217147 NZ_CP113917:c369142-368891 [Bifidobacterium sp. ESL0775]
ATGAGCAGCGCAACCATCGCAGTACGTACCGATCCGGAAGTCAAGAAGGAAGCACAGGAAGTGCTGAAAAGCATCGGCCT
TGATATGAGCGGCGCCATCAACATCTTCCTTCGCCAAGTCATCAGCGACCAAGGCCTCCCCTTTCGCCCCAAGCGCGACG
CTTTCGAAACCCGAGTACAAAAAGCAATGAACAGCGGCACCCGTACTTTCGACAACGTCGACGATCTCATGGATGAGTTA
CGGAATGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References