Detailed information of TA system TA021713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1832918..1833437
• Replicon: chromosome
• Accession: NC_008391
• Organism: Burkholderia ambifaria AMMD

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q0B638
• Locus tag: BAMB_RS24190
• Protein ID: WP_011659780.1
• Coordinates: 1832918..1833199 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q0B637
• Locus tag: BAMB_RS24195
• Protein ID: WP_011659781.1
• Coordinates: 1833189..1833437 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMB_RS24170	1828574..1829272	-	699	WP_011659777.1	MgtC/SapB family protein	-
BAMB_RS24175	1829384..1830493	+	1110	WP_041491549.1	AGE family epimerase/isomerase	-
BAMB_RS24180	1830466..1832091	-	1626	WP_011659779.1	Tar ligand binding domain-containing protein	-
BAMB_RS24185	1832352..1832795	+	444	WP_006757720.1	PaaI family thioesterase	-
BAMB_RS24190	1832918..1833199	-	282	WP_011659780.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAMB_RS24195	1833189..1833437	-	249	WP_011659781.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BAMB_RS24200	1833580..1834632	-	1053	WP_011659782.1	CoA transferase	-
BAMB_RS24205	1834991..1836181	-	1191	WP_011659783.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10930.84 Da
• Isoelectric Point: 10.3961

>T21713 WP_011659780.1 NC_008391:c1833199-1832918 [Burkholderia ambifaria AMMD]
MTFELAFLEPALKEWKKLDRTICDQFKSRLAERLENPRIASAKLHGHPDRYKIKLRSVGYRLVYEVRDTEVIVLVVAVGR
RDRDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T21713 NC_008391:c1833199-1832918 [Burkholderia ambifaria AMMD]
ATGACCTTTGAGCTTGCCTTTCTCGAACCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCATCTGCGACCAGTTCAA
ATCCCGACTCGCCGAGCGCCTCGAGAATCCCCGCATTGCGTCGGCCAAGCTGCATGGCCATCCGGATCGCTACAAGATCA
AGCTGCGCAGCGTCGGCTACCGACTCGTCTACGAAGTGCGCGATACGGAAGTGATCGTACTGGTTGTCGCAGTCGGTCGC
CGTGACCGCGATGCCGTCTATCTTGCCGCGATGAAGCGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8989.36 Da
• Isoelectric Point: 5.6566

>AT21713 WP_011659781.1 NC_008391:c1833437-1833189 [Burkholderia ambifaria AMMD]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALANTRAKDKVVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT21713 NC_008391:c1833437-1833189 [Burkholderia ambifaria AMMD]
ATGCCTCACACCATTCTGGCCAATGTTACGGCGAGCGTTTCGGAACTGAAGCGCAATCCGATGGGAACCGTCGCGGCGGG
CGAGGGCTTTCCGGTTGCGATTCTGAATCACAACGAGCCCGCGTTCTATTGCATCCCGGCGAAGACGTGGGAAGCGATGG
TCGAACGTCTCGAAGATATAGAAGACAACGCGCTTGCCAATACGCGTGCGAAGGACAAGGTCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Toxin

• AlphaFold DB: Q0B638

Antitoxin

• AlphaFold DB: Q0B637