Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4491779..4492611 | Replicon | chromosome |
| Accession | NZ_CP083701 | ||
| Organism | Escherichia coli strain SUISSEKPC3NDM5 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | K9O95_RS21960 | Protein ID | WP_000854765.1 |
| Coordinates | 4491779..4492153 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7U9IW59 |
| Locus tag | K9O95_RS21965 | Protein ID | WP_001360327.1 |
| Coordinates | 4492243..4492611 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9O95_RS21925 (4486856) | 4486856..4487455 | + | 600 | WP_001255034.1 | type II secretion system minor pseudopilin GspJ | - |
| K9O95_RS21930 (4487458) | 4487458..4488435 | + | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| K9O95_RS21935 (4488432) | 4488432..4489610 | + | 1179 | WP_000094986.1 | type II secretion system protein GspL | - |
| K9O95_RS21940 (4489612) | 4489612..4490148 | + | 537 | WP_000942793.1 | GspM family type II secretion system protein YghD | - |
| K9O95_RS21945 (4490430) | 4490430..4491272 | - | 843 | WP_022645115.1 | DUF4942 domain-containing protein | - |
| K9O95_RS21950 (4491357) | 4491357..4491551 | - | 195 | WP_024181941.1 | DUF957 domain-containing protein | - |
| K9O95_RS21955 (4491576) | 4491576..4491779 | - | 204 | WP_001398797.1 | DUF5983 family protein | - |
| K9O95_RS21960 (4491779) | 4491779..4492153 | - | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| K9O95_RS21965 (4492243) | 4492243..4492611 | - | 369 | WP_001360327.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K9O95_RS21970 (4492774) | 4492774..4492995 | - | 222 | WP_023356553.1 | DUF987 domain-containing protein | - |
| K9O95_RS21975 (4493058) | 4493058..4493534 | - | 477 | WP_022645117.1 | RadC family protein | - |
| K9O95_RS21980 (4493550) | 4493550..4494029 | - | 480 | WP_001564060.1 | antirestriction protein | - |
| K9O95_RS21985 (4494129) | 4494129..4494269 | + | 141 | WP_000997937.1 | hypothetical protein | - |
| K9O95_RS21990 (4494295) | 4494295..4495113 | - | 819 | WP_001175165.1 | DUF932 domain-containing protein | - |
| K9O95_RS21995 (4495203) | 4495203..4495436 | - | 234 | WP_001278293.1 | DUF905 family protein | - |
| K9O95_RS22000 (4495442) | 4495442..4496119 | - | 678 | WP_001097302.1 | hypothetical protein | - |
| K9O95_RS22005 (4496267) | 4496267..4496947 | - | 681 | WP_001282921.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T217115 WP_000854765.1 NZ_CP083701:c4492153-4491779 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T217115 NZ_CP113832:2684835-2684939 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.34 Da Isoelectric Point: 5.9598
>AT217115 WP_001360327.1 NZ_CP083701:c4492611-4492243 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT217115 NZ_CP113832:c2685127-2684872 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A7ZVJ9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9IW59 |