Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3086018..3086613 Replicon chromosome
Accession NZ_CP083701
Organism Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag K9O95_RS15225 Protein ID WP_000239579.1
Coordinates 3086018..3086368 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag K9O95_RS15230 Protein ID WP_001223208.1
Coordinates 3086362..3086613 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O95_RS15205 (3081467) 3081467..3082489 - 1023 WP_001353963.1 ABC transporter permease -
K9O95_RS15210 (3082503) 3082503..3084005 - 1503 WP_000210557.1 sugar ABC transporter ATP-binding protein -
K9O95_RS15215 (3084145) 3084145..3085101 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
K9O95_RS15220 (3085411) 3085411..3085941 + 531 WP_000055072.1 inorganic diphosphatase -
K9O95_RS15225 (3086018) 3086018..3086368 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
K9O95_RS15230 (3086362) 3086362..3086613 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
K9O95_RS15235 (3086825) 3086825..3087166 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
K9O95_RS15240 (3087169) 3087169..3090948 - 3780 WP_053276653.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T217110 WP_000239579.1 NZ_CP083701:c3086368-3086018 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T217110 NZ_CP113832:c2547806-2547705 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT217110 WP_001223208.1 NZ_CP083701:c3086613-3086362 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT217110 NZ_CP113832:2547586-2547760 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References