Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2328266..2328884 Replicon chromosome
Accession NZ_CP083701
Organism Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag K9O95_RS11550 Protein ID WP_001291435.1
Coordinates 2328666..2328884 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag K9O95_RS11545 Protein ID WP_000344800.1
Coordinates 2328266..2328640 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O95_RS11535 (2323355) 2323355..2324548 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9O95_RS11540 (2324571) 2324571..2327720 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
K9O95_RS11545 (2328266) 2328266..2328640 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
K9O95_RS11550 (2328666) 2328666..2328884 + 219 WP_001291435.1 HHA domain-containing protein Toxin
K9O95_RS11555 (2329056) 2329056..2329607 + 552 WP_000102564.1 maltose O-acetyltransferase -
K9O95_RS11560 (2329723) 2329723..2330193 + 471 WP_000136192.1 YlaC family protein -
K9O95_RS11565 (2330357) 2330357..2331907 + 1551 WP_064221513.1 cyclic-guanylate-specific phosphodiesterase PdeB -
K9O95_RS11570 (2331949) 2331949..2332302 - 354 WP_000878140.1 DUF1428 domain-containing protein -
K9O95_RS11580 (2332681) 2332681..2332992 + 312 WP_000409911.1 MGMT family protein -
K9O95_RS11585 (2333023) 2333023..2333595 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217106 WP_001291435.1 NZ_CP083701:2328666-2328884 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T217106 NZ_CP113831:2933004-2933147 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT217106 WP_000344800.1 NZ_CP083701:2328266-2328640 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT217106 NZ_CP113831:c2933341-2933079 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References