Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1643319..1644163 Replicon chromosome
Accession NZ_CP083701
Organism Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag K9O95_RS08325 Protein ID WP_000854686.1
Coordinates 1643319..1643702 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag K9O95_RS08330 Protein ID WP_001285602.1
Coordinates 1643783..1644163 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O95_RS08285 (1638321) 1638321..1638812 - 492 WP_001300785.1 DUF1097 domain-containing protein -
K9O95_RS08290 (1638914) 1638914..1639468 - 555 WP_001001921.1 molecular chaperone YcdY -
K9O95_RS08295 (1639492) 1639492..1640229 - 738 WP_000283667.1 zinc-binding phosphatase -
K9O95_RS08300 (1640284) 1640284..1641222 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
K9O95_RS08310 (1641693) 1641693..1642535 - 843 WP_001431817.1 DUF4942 domain-containing protein -
K9O95_RS08315 (1642620) 1642620..1642817 - 198 WP_000839253.1 DUF957 domain-containing protein -
K9O95_RS08320 (1642834) 1642834..1643322 - 489 WP_001054233.1 DUF5983 family protein -
K9O95_RS08325 (1643319) 1643319..1643702 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
K9O95_RS08330 (1643783) 1643783..1644163 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K9O95_RS08335 (1644174) 1644174..1644857 - 684 WP_000086768.1 hypothetical protein -
K9O95_RS08340 (1644876) 1644876..1645097 - 222 WP_000692298.1 DUF987 domain-containing protein -
K9O95_RS08345 (1645160) 1645160..1645636 - 477 WP_001186726.1 RadC family protein -
K9O95_RS08350 (1645652) 1645652..1646137 - 486 WP_000214307.1 antirestriction protein -
K9O95_RS08355 (1646229) 1646229..1647047 - 819 WP_001234732.1 DUF932 domain-containing protein -
K9O95_RS08360 (1647147) 1647147..1647380 - 234 WP_001119717.1 DUF905 family protein -
K9O95_RS08365 (1647459) 1647459..1647914 - 456 WP_001504120.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 1634702..1667174 32472


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T217105 WP_000854686.1 NZ_CP083701:c1643702-1643319 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T217105 NZ_CP113831:c2927484-2927143 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACGCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT217105 WP_001285602.1 NZ_CP083701:c1644163-1643783 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT217105 NZ_CP113831:c2927714-2927484 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References