Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1147097..1147735 Replicon chromosome
Accession NZ_CP083701
Organism Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag K9O95_RS05710 Protein ID WP_000813794.1
Coordinates 1147559..1147735 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K9O95_RS05705 Protein ID WP_001270286.1
Coordinates 1147097..1147513 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O95_RS05685 (1142249) 1142249..1143190 - 942 WP_001251313.1 ABC transporter permease -
K9O95_RS05690 (1143191) 1143191..1144204 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
K9O95_RS05695 (1144222) 1144222..1145367 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
K9O95_RS05700 (1145612) 1145612..1147018 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
K9O95_RS05705 (1147097) 1147097..1147513 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
K9O95_RS05710 (1147559) 1147559..1147735 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
K9O95_RS05715 (1147957) 1147957..1148187 + 231 WP_000494244.1 YncJ family protein -
K9O95_RS05720 (1148279) 1148279..1150240 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
K9O95_RS05725 (1150313) 1150313..1150849 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
K9O95_RS05730 (1150941) 1150941..1152116 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T217104 WP_000813794.1 NZ_CP083701:c1147735-1147559 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T217104 NZ_CP113831:c2855192-2855049 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT217104 WP_001270286.1 NZ_CP083701:c1147513-1147097 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT217104 NZ_CP113831:2854930-2855075 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References