Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1022022..1023787 Replicon chromosome
Accession NC_008391
Organism Burkholderia ambifaria AMMD

Toxin (Protein)


Gene name doc Uniprot ID Q0B870
Locus tag BAMB_RS20555 Protein ID WP_011659095.1
Coordinates 1022876..1023787 (-) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q0B871
Locus tag BAMB_RS20550 Protein ID WP_011659094.1
Coordinates 1022022..1022879 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMB_RS20530 1017159..1018649 - 1491 WP_011659090.1 aldehyde dehydrogenase -
BAMB_RS20535 1018748..1019575 - 828 WP_011659091.1 aspartate dehydrogenase -
BAMB_RS20540 1019568..1021235 - 1668 WP_011659092.1 thiamine pyrophosphate-binding protein -
BAMB_RS20545 1021228..1022025 - 798 WP_011659093.1 SDR family oxidoreductase -
BAMB_RS20550 1022022..1022879 - 858 WP_011659094.1 IclR family transcriptional regulator Antitoxin
BAMB_RS20555 1022876..1023787 - 912 WP_011659095.1 alpha/beta fold hydrolase Toxin
BAMB_RS20560 1023807..1024334 - 528 WP_006751280.1 cupin domain-containing protein -
BAMB_RS20565 1024374..1025144 - 771 WP_011659096.1 SDR family oxidoreductase -
BAMB_RS20570 1025137..1026207 - 1071 WP_011659097.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BAMB_RS20575 1026262..1026573 - 312 WP_011659098.1 hypothetical protein -
BAMB_RS20580 1026575..1026892 - 318 WP_006751284.1 non-heme iron oxygenase ferredoxin subunit -
BAMB_RS20585 1027343..1028422 + 1080 WP_011659099.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, C-terminal

(144-266)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31306.55 Da        Isoelectric Point: 6.5933

>T21710 WP_011659095.1 NC_008391:c1023787-1022876 [Burkholderia ambifaria AMMD]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHDASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PAETRDTRRDARLAMLDELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA

Download         Length: 912 bp

>T21710 NC_008391:c1023787-1022876 [Burkholderia ambifaria AMMD]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGTGCCAGCTCGACACGCTCGGCGCGTCGCGA
CGCGTGCTTGCGTGGGATGCGCCCGGCTACGGCGTGTCGACCCCCGTGCACGACGCGTCGCCGACCGCCGCCGATTACGC
GGCGTCGCTGAATGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCG
CGGGCGGCCTGTGCCGCCTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCCGTGCG
CCCGCCGAAACGCGCGACACGCGCCGCGACGCGCGCCTCGCGATGCTCGACGAACTCGGTCCGGCCGGGCTCGCCGAGCA
GCGCAGTGGCAACATGCTGTCGGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTATGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTCCGCGGCCGCACG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAATT
GCAGGTGATTCCGCAGGCCGGTCATGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCGTCGCTTATCGACACGTTCTGTC
GTCAGTGCGACACGCAGCGAGGCATGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31403.94 Da        Isoelectric Point: 6.3573

>AT21710 WP_011659094.1 NC_008391:c1022879-1022022 [Burkholderia ambifaria AMMD]
MSEPLQQPESDSTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEMIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT21710 NC_008391:c1022879-1022022 [Burkholderia ambifaria AMMD]
ATGAGCGAACCGCTGCAACAACCAGAATCCGACAGCACCAAGGCCGACGCCGGCTACGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGTGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCGGACAAGGATCGCAACTACAAG
CTGGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGTGCCAGTCGCCGGTGTTCAGCGCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGTGCGCTGTATCCGGAAGGCACGCTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGATGCGCTGTACGAAATGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGAGGCGCTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q0B870

Antitoxin

Source ID Structure
AlphaFold DB Q0B871

References